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The 200-MeV proton therapy project at the Paul Scherrer Institute: conceptual design and practical realization.

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TLDR
The new proton therapy facility is being assembled at the Paul Scherrer Institute (PSI) and the status of the facility and first experimental results are introduced for later reference.
Abstract
The new proton therapy facility is being assembled at the Paul Scherrer Institute (PSI). The beam delivered by the PSI sector cyclotron can be split and brought into a new hall where it is degraded from 590 MeV down to an energy in the range of 85-270 MeV. A new beam line following the degrader is used to clean the low-energetic beam in phase space and momentum band. The analyzed beam is then injected into a compact isocentric gantry, where it is applied to the patient using a new dynamic treatment modality, the so-called spot-scanning technique. This technique will permit full three-dimensional conformation of the dose to the target volume to be realized in a routine way without the need for individualized patient hardware like collimators and compensators. By combining the scanning of the focused pencil beam within the beam optics of the gantry and by mounting the patient table eccentrically on the gantry, the diameter of the rotating structure has been reduced to only 4 m. In the article the degrees of freedom available on the gantry to apply the beam to the patient (with two rotations for head treatments) are also discussed. The devices for the positioning of the patient on the gantry (x rays and proton radiography) and outside the treatment room (the patient transporter system and the modified mechanics of the computer tomograph unit) are briefly presented. The status of the facility and first experimental results are introduced for later reference.

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Absorbed Dose Determination in External Beam Radiotherapy: An International Code of Practice for Dosimetry based on Standards of Absorbed Dose to Water

TL;DR: This poster presents a probabilistic procedure for estimating the intensity values of radiolysis-like particles in the presence of X-ray diffraction waves.
Journal ArticleDOI

Heavy-ion tumor therapy: Physical and radiobiological benefits

TL;DR: Results of clinical phase I-II trials provide evidence that carbon-ion radiotherapy might be beneficial in several tumor entities, and the progress in heavy-ion therapy is reviewed, including physical and technical developments, radiobiological studiesmore and models, as well as radiooncological studies.
Journal ArticleDOI

Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization.

TL;DR: A novel code system, TRiP, dedicated to the planning of radiotherapy with energetic ions, in particular 12C, designed to cooperate with three-dimensional active dose shaping devices like the GSI raster scan system is described.
Journal ArticleDOI

Intensity modulation methods for proton radiotherapy.

TL;DR: It is concluded that the 3D method provides the greatest flexibility for constructing conformal doses in challenging situations, but that when large numbers of beam ports are available, little advantage may be gained from the additional modulation of intensity in depth.
Journal ArticleDOI

The physics of proton therapy

TL;DR: The basic aspects of the physics of proton therapy are reviewed, including proton interaction mechanisms, proton transport calculations, the determination of dose from therapeutic and stray radiations, and shielding design.
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