The 2001 Bethesda System: terminology for reporting results of cervical cytology.
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...testing, STD clinics should use CLIA certified laboratories (421) and those that report cytopathology findings according to the following Bethesda 2001 terminology (422): atypical squamous cells (ASC), low-grade squamous intraepithelial lesions (LSIL), and high-grade intraepithelial lesions (HSIL)....
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"The 2001 Bethesda System: terminolo..." refers background in this paper
...However, there has been a shift in the United States with regard to management based on the recognition that most LSIL, especially in young women, represents a self-limited human papillomavirus (HPV) infection.(5) Accordingly, the current emphasis is on detection and treatment of histologically confirmed high-grade disease (particularly cervical intraepithelial neoplasia [CIN] 3)....
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"The 2001 Bethesda System: terminolo..." refers methods in this paper
...The dichotomous division of SIL reflects the substantial virological, molecular, and clinical evidence that LSIL is generally a transient infection with HPV, while HSIL is more often associated with viral persistence and higher risk for progression.(10-13) In addition, data from the ASCUS LSIL Triage Study demonstrate the following: (1) LSIL vs HSIL is a fairly reproducible diagnostic breakpoint, (2) subdividing cytological HSIL into moderate and severe dysplasia or CIN 2 and 3 is not very reproducible, and (3) HPV cytopathic effect cannot be reliably separated from mild dysplasia or CIN 1 (M....
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"The 2001 Bethesda System: terminolo..." refers background in this paper
...Estimates suggest that 10% to 20% of women with ASC have underlying CIN 2 or 3 and that 1 in 1000 may have invasive cancer.(6) The elimination of an equivocal cytology category seemed imprudent given the high expectations for very sensitive cervical cytological screening in the United States....
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