The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia
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...Eight balanced translocations and inversions, and their variants, are included in the WHO category “AML with recurrent genetic abnormalities”.(3,4) Nine balanced rearrangements and multiple unbalanced abnormalities are sufficient to establish the WHO diagnosis of “AML with...
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...2 Immunophenotyping Table 3 provides a list of markers helpful for establishing the diagnosis of AML,(48) as well as specific lineage markers useful for defining mixed-phenotype acute leukemia.(3,4)...
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...This article provides updated recommendations that parallel the current update to the World Health Organization classification of myeloid neoplasms and acute leukemia.(3,4) For diagnosis and management of acute promyelocytic leukemia readers are referred to the respective recommendations....
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...Importantly, acquired clonal mutations identical to those seen inMDS can occur in the hematopoietic cells of apparently healthy older individuals without MDS, so-called “clonal hematopoiesis of indeterminate potential” (CHIP).(30,31,61) Although some patients with CHIP subsequently developMDS, the natural history of this condition is not yet fully understood; thus, the presence of MDS-associated somatic mutations alone is not considered diagnostic of MDS in this classification, even inapatientwith unexplainedcytopenia,where these mutations may be commonly found....
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"The 2016 revision to the World Heal..." refers background in this paper
...The myeloblast percentage, as determined by counting wellprepared, cellular BM aspirate smears and/or touch preparations and a PB smear, remains critical in defining theWHOMDScategories and as risk strata in the Revised International Prognostic Scoring System (IPSS-R).(54) The presence of 1%blasts in the PB,with,5%BMblasts, defines 1 type ofMDS, unclassifiable (MDS-U)....
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