The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
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TLDR
Southern hybridization analysis of human genomic DNA indicates a multigene system for aldose reductase, suggesting the existence of additional proteins, and the aldo-keto reductases superfamily of proteins may have a more significant and hitherto not fully appreciated role in general cellular metabolism.About:
This article is published in Journal of Biological Chemistry.The article was published on 1989-06-05 and is currently open access. It has received 434 citations till now. The article focuses on the topics: Aldo-keto reductase & Aldehyde Reductase.read more
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Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray.
Rajesh K. Thimmulappa,Kim H. Mai,Sorachai Srisuma,Thomas W. Kensler,Masayuki Yamamoto,Shyam Biswal +5 more
TL;DR: This investigation expands the horizon of Nrf2-regulated genes, highlights the cross-talk between various metabolic pathways, and divulges the pivotal role played by NRF2 in regulating cellular defenses against carcinogens and other toxins.
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11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response.
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11 beta-Hydroxysteroid dehydrogenase.
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Molecular characterization of the stretch-induced adaptation of cultured cardiac cells. An in vitro model of load-induced cardiac hypertrophy.
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Vitamin C. Biosynthesis, recycling and degradation in mammals.
TL;DR: The degradation of vitamin’C in mammals is initiated by the hydrolysis of dehydroascorbate to 2,3‐diketo‐l‐gulonate, which is spontaneously degraded to oxalate, CO2 and l‐erythrulose, at variance with bacteria such as Escherichia coli, which have enzymatic degradation pathways for ascorbate and probably also dehydroASCorbate.
References
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Molecular Cloning: A Laboratory Manual
TL;DR: Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years as mentioned in this paper and has been so popular, or so influential, that no other manual has been more widely used and influential.
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Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.
TL;DR: In this article, the rat pancreas RNA was used as a source for the purification of alpha-amylase messenger ribonucleic acid (RBA) using 2-mercaptoethanol.
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A new method for sequencing DNA
Allan M. Maxam,Walter Gilbert +1 more
TL;DR: Reactions that cleave DNA preferentially at guanines, at adenines,At cytosines and thymines equally, and at cytosine alone are described.
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Supercoil sequencing: a fast and simple method for sequencing plasmid DNA
Ellson Y. Chen,Peter H. Seeburg +1 more
TL;DR: A method for obtaining sequence information directly from plasmid DNA is presented, and the advantages include speed, simplicity, avoidance of additional cloning steps into single-stranded phage M13 vectors, and hence applicability to sequencing large numbers of samples.
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DNA sequence analysis with a modified bacteriophage T7 DNA polymerase
TL;DR: A chemically modified phage T7 DNA polymerase has three properties that make it ideal for DNA sequencing by the chain-termination method; the enzyme is highly processive, catalyzing the polymerization of thousands of nucleotides without dissociating, and processive synthesis with dITP in place of dGTP eliminates band compressions.