The amino acid sequences of the Fd fragments of two human gamma-1 heavy chains
Elizabeth M. Press,Nancy Hogg +1 more
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The amino acid sequences of the Fd fragments of two human pathological Immunoglobulins of the immunoglobulin G1 class are reported and it is shown that the heavy-chain variable regions are similar in length to those of the light chains.Abstract:
The amino acid sequences of the Fd fragments of two human pathological immunoglobulins of the immunoglobulin G1 class are reported. Comparison of the two sequences shows that the heavy-chain variable regions are similar in length to those of the light chains. The existence of heavy chain variable region subgroups is also deduced, from a comparison of these two sequences with those of another gamma 1 chain, Eu, a mu chain, Ou, and the partial sequence of a fourth gamma 1 chain, Ste. Carbohydrate has been found to be linked to an aspartic acid residue in the variable region of one of the gamma 1 chains, Cor.read more
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Three-Dimensional Structure of the Fab′ Fragment of a Human Immunoglobulin at 2.8-Å Resolution
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Hypervariable regions, idiotypy, and the antibody-combining site.
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Carbohydrate moiety of HLA antigens. Antigenic properties and amino acid sequences around the site of glycosylation.
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