The amnesic effect of diazepam (valium)
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It is considered that the memory difficulties were not due to serious reduction of level of consciousness but do focus on the input or “consolidation” processes rather than on retrieval.Abstract:
SUMMARY A double-blind trial of intravenous diazepam (0.24 mg/kg) versus saline was carried out on twelve young intelligent male volunteers to examine the amnesic effect of the drug. Complex psychological testing extended over a 2-hour period. Dense anterograde amnesia was found for approximately 10 minutes with a less severe impairment of memory persisting at least half an hour after injection. It is considered that the memory difficulties were not due to serious reduction of level of consciousness but do focus on the input or “consolidation” processes rather than on retrieval. Further studies are needed to define more clearly the nature of the deficit.read more
Citations
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Psychomotor Function and Psychoactive Drugs
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The amnesic action of benzodiazepines in man
TL;DR: The amnesia appears to be characteristic of all benzodiazepines and may be related to the sedative action of these compounds but evidence on the latter point is inconclusive, and the importance of the amnesic action in a population of clinically anxious outpatients taking benzdiazepines over an extended period remains to be investigated.
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Tranquillising memories: a review of the effects of benzodiazepines on human memory.
TL;DR: There is some evidence that partial tolerance to amnesic effects develops with repeated doses of diazepam, but research with other benzodiazepines is inconclusive.
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The Neuropsychology of Autobiographical Memory
TL;DR: A full model of autobiographical memory must consider cognitive processes that are not generally considered 'core processes,' as well as the brain regions upon which these processes depend.
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Effects of diazepam and scopolamine on storage, retrieval and organizational processes in memory.
Mohamed M. Ghoneim,S. P. Mewaldt +1 more
TL;DR: Both diazepam and scopolamine impaired memory functions although the action of the latter drug was more pronounced and prolonged and the deficit appeared to be in the storage process leaving retrieval processes unaffected.
References
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Wilder Penfield,Brenda Milner +1 more
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Retrograde amnesia produced by anesthetic and convulsant agents.
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Clinical studies of induction agents. XXV. Diazepam.
Stuart Brown,John W. Dundee +1 more
TL;DR: Diazepam has been studied as an intravenous induction agent in intermittent and sinle doses and there was a remarkable absence of cardiovascular or other side effects, even from very large doses, and amnesia was also an outstanding feature.
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