Journal ArticleDOI
The Antimicrobial Peptide LL-37 Inhibits HIV-1 Replication
Reads0
Chats0
TLDR
It is demonstrated that LL-37 inhibits HIV-1 replication in PBMC, including primary CD4(+) T cells, and the HIV- 1 inhibitory effect was shown to be independent of FPRL-1 signalling.Abstract:
The antimicrobial peptide LL-37 is the only cathelicidin that has been described in humans. LL-37 exerts chemotactic, immunomodulatory and angiogenic effects; activities that are mediated through binding to the formyl peptide receptor like (FPRL)-1 receptor. Agonistic ligation of FPRL-1 can also induce down-regulation of HIV-1 chemokine receptors and reduce susceptibility to HIV-1 infection in vitro. Therefore, we have evaluated the capacity of LL-37 to inhibit HIV-1 infection in vitro. Here we demonstrate that LL-37 inhibits HIV-1 replication in PBMC, including primary CD4(+) T cells. This inhibition was readily reproduced using various HIV-1 isolates without detectable changes in the target cell expression of HIV-1 chemokine receptors. Accordingly, the HIV-1 inhibitory effect was shown to be independent of FPRL-1 signalling. Given the epithelial expression of LL-37, it may contribute to the local protection against HIV-1 infection.read more
Citations
More filters
Journal ArticleDOI
Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity.
John S. Adams,Martin Hewison +1 more
TL;DR: Observations suggest that nonclassical metabolism and response to vitamin D might have a significant role in human physiology beyond skeletal and calcium homeostasis.
Journal ArticleDOI
Antimicrobial host defence peptides: functions and clinical potential
TL;DR: The emerging potential to therapeutically harness cationic host defence peptides to treat infectious diseases, chronic inflammatory disorders and wound healing is assessed, highlighting current preclinical studies and clinical trials.
Journal ArticleDOI
An update on vitamin D and human immunity.
TL;DR: The conclusion from these reports is that many nonclassical actions of vitamin D are independent of conventional vitamin D endocrinology and are therefore more sensitive to variations in vitamin D status.
Journal ArticleDOI
Human Antimicrobial Peptides and Proteins
TL;DR: It appears that granulysin enters cells and kills intracellular pathogens with the aid of pore-forming perforin, opening new avenues to the development of anti-infectious drugs.
Journal ArticleDOI
Vitamin D3: a helpful immuno-modulator
TL;DR: This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune‐regulatory effects of vitamin D3 on immune cells.
Related Papers (5)
Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
Philip T. Liu,Steffen Stenger,Huiying Li,Linda Wenzel,Belinda H. Tan,Stephan R. Krutzik,Maria Teresa Ochoa,Jürgen Schauber,Kent Wu,Christoph Meinken,Diane L. Kamen,Manfred Wagner,Robert Bals,Andreas Steinmeyer,Ulrich Zügel,Richard L. Gallo,David Eisenberg,Martin Hewison,Bruce W. Hollis,John S. Adams,Barry R. Bloom,Robert L. Modlin +21 more