The Argus II epiretinal prosthesis system allows letter and word reading and long-term function in patients with profound vision loss
Lyndon da Cruz,Brian Coley,Jessy D. Dorn,Francesco Merlini,Eugene Filley,Punita Christopher,Fred K. Chen,Fred K. Chen,Varalakshmi Wuyyuru,José Sahel,Paulo E. Stanga,Mark S. Humayun,Robert J. Greenberg,Gislin Dagnelie +13 more
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TLDR
Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution, represents significant progress in the evolution of artificial sight.Abstract:
Background Retinal prosthesis systems (RPS) are a novel treatment for profound vision loss in outer retinal dystrophies. Ideal prostheses would offer stable, longterm retinal stimulation and reproducible spatial resolution in a portable form appropriate for daily life. Methods We report a prospective, internally controlled, multicentre trial of the Argus II system. Twenty-eight subjects with light perception vision received a retinal implant. Controlled, closed-group, forced-choice letter identification, and, open-choice two-, three- and fourletter word identification tests were carried out. Results The mean±SD percentage correct letter identification for 21 subjects tested were: letters L, T, E, J, F, H, I, U, 72.3±24.6% system on and 17.7±12.9% system off; letters A, Z, Q, V, N, W, O, C, D, M, 55.0 ±27.4% system on and 11.8%±10.7% system off, and letters K, R, G, X, B, Y, S, P, 51.7±28.9% system on and 15.3±7.4% system off. (p<0.001 for all groups). A subgroup of six subjects was able to consistently read letters of reduced size, the smallest measuring 0.9 cm (1.7°) at 30 cm, and four subjects correctly identify unrehearsed two-, three- and four-letter words. Average implant duration was 19.9 months. Conclusions Multiple blind subjects fitted with the Argus II system consistently identified letters and words using the device, indicating reproducible spatial resolution. This, in combination with stable, long-term function, represents significant progress in the evolution of artificial sight.read more
Citations
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Wireless Power Transfer Strategies for Implantable Bioelectronics
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TL;DR: The recent clinical trials are reviewed and technology breakthroughs that will contribute to next generation of retinal prostheses are highlighted.
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First-in-Human Trial of a Novel Suprachoroidal Retinal Prosthesis
Lauren N Ayton,Peter J. Blamey,Robyn H. Guymer,Chi D Luu,David A X Nayagam,Nicholas C. Sinclair,Mohit N. Shivdasani,Jonathan Yeoh,Mark McCombe,Robert Briggs,Nicholas L. Opie,Joel Villalobos,Peter N. Dimitrov,Mary Varsamidis,Matthew A. Petoe,Chris McCarthy,Janine G. Walker,Nick Barnes,Anthony N. Burkitt,Chris E. Williams,Robert K. Shepherd,Penelope J Allen +21 more
TL;DR: The first-in-human Phase 1 trial to investigate the use of retinal implants in the suprachoroidal space in three human subjects with end-stage retinitis pigmentosa holds promise for the field of vision restoration.
Journal ArticleDOI
The Argus II Retinal Prosthesis System
TL;DR: The Argus(®) II as discussed by the authors is the first prosthetic vision device to obtain regulatory approval in both Europe and the USA, and it has entered the commercial market as a treatment for patients with profound vision loss from end-stage outer retinal disease, predominantly retinitis pigmentosa.
Book Chapter
The Argus II Retinal Prosthesis System
Edward Bloch,L Da Cruz +1 more
TL;DR: A sufficiently robust safety profile was demonstrated in the phase I/II clinical trial of 30 patients, and improvement of function in terms of orientation and mobility, target localisation, shape and object recognition, and reading of letters and short unrehearsed words have also been shown.
References
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Visual perception in a blind subject with a chronic microelectronic retinal prosthesis
Mark S. Humayun,James D. Weiland,Gildo Y. Fujii,Robert J. Greenberg,Richard Williamson,James Singleton Little,Brian V. Mech,Valerie Cimmarusti,Gretchen B. Van Boemel,Gislin Dagnelie,Eugene de Juan +10 more
TL;DR: A retinal prosthesis was permanently implanted in the eye of a completely blind test subject and the subject was able to see perceptions of light (spots) on all 16 electrodes of the array.
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Visual acuities "hand motion" and "counting fingers" can be quantified with the freiburg visual acuity test.
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Alan Y. Chow,Vincent Y. Chow,Kirk H. Packo,John S. Pollack,Gholam A. Peyman,Ronald A. Schuchard +5 more
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