The Biochemistry of Molybdenum
About: This article is published in Studies in Inorganic Chemistry.The article was published on 1994-01-01. It has received 3 citations till now. The article focuses on the topics: Molybdenum.
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TL;DR: Pore water and sediment Mo concentrations were measured in a suite of multicores collected at four sites along the northeastern flank of the Santa Barbara Basin to examine the connection between authigenic Mo formation and pore water sulfide concentration.
441 citations
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...Molybdenum is a biologically-essential element (Williams, 1994), but it is not known whether significant amounts of biogenic Mo exist in plankton matter, and whether it is easily regenerated from biogenic detritus if it exists....
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TL;DR: In this paper, the authors describe the Funktionen von proteingebundenem Kupfer vor allem im Metabolismus von O2 and N/O-Verbindungen (NO2−, N2O) sowie seine haufige Assoziation with oxidierenden organischen and anorganischen Radikalen wie etwa Tyrosyl, Semichinonen, Superoxid-Ionen, Nitrosyls or NitroSyl-Radikalens.
Abstract: Kupfer ist ein bioessentielles Element, das in den beiden relevanten Oxidationsstufen I und II einzigartige chemische Eigenschaften aufweist. Biochemische, molekularbiologische und medizinische Erkenntnisse einerseits sowie die Synthese und Untersuchung niedermolekularer “Modell”-Komplexverbindungen andererseits haben in den letzten Jahren zu wesentlichen Fortschritten bei der Erforschung der teilweise uberraschenden Biochemie dieses Spurenelements gefuhrt. Auffallend, jedoch aufgrund des chemischen und des vermuteten evolutionsgeschichtlichen Hintergrundes nachvollziehbar, sind die Funktionen von proteingebundenem Kupfer vor allem im Metabolismus von O2 und N/O-Verbindungen (NO2−, N2O) sowie seine haufige Assoziation mit oxidierenden organischen und anorganischen Radikalen wie etwa Tyrosyl, Semichinonen, Superoxid-Ionen oder Nitrosyl-Radikalen.
92 citations
TL;DR: The specificity exhibited by the molybdate binding protein ModA for molyBdate and tungstate reflects the size and ligands of the anion binding pocket.
Abstract: The specificity exhibited by the molybdate binding protein ModA for molybdate and tungstate reflects the size and ligands of the anion binding pocket.
71 citations
References
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01 Jan 1976
73 citations
TL;DR: It is concluded that the molybdenum iron-sulphur protein originally isolated from Desulfovibrio gigas is a form of an aldehyde oxidase or dehydrogenase, which may represent a primitive form of the enzyme rather than a degradation product.
Abstract: The molybdenum iron-sulphur protein originally isolated from Desulfovibrio gigas by Moura, Xavier, Bruschi, Le Gall, Hall & Cammack [(1976) Biochem. Biophys. Res. Commun. 72, 782-789] has been further investigated by e.p.r. spectroscopy of molybdenum(V). The signal obtained on extended reduction of the protein with sodium dithionite has been shown, by studies at 9 and 35 HGz in 1H2O and 2H2O and computer simulations, to have parameters corresponding to those of the Slow signal from the inactive desulpho form of various molybdenum-containing hydroxylases. Another signal obtained on brief reduction of the protein with small amounts of dithionite was shown by e.p.r. difference techniques to be a Rapid type 2 signal, like that from the active form of such enzymes. In confirmation that the protein is a molybdenum-containing hydroxylase, activity measurements revealed that it had aldehyde:2,6-dichlorophenol-indophenol oxidoreductase activity. No such activity towards xanthine or purine was observed. Salicylaldehyde was a particularly good substrate, and treatment of the protein with it also gave rise to the Rapid signal. Molybdenum cofactor liberated from the protein was active in the nit-1 Neurospora crassa nitrate reductase assay. It is concluded that the protein is a form of an aldehyde oxidase or dehydrogenase. From the intensity of the e.p.r. signals and from enzyme activity measurements, 10-30% of the protein in the sample examined appeared to be in the functional form. The evolutionary significance of the protein, which may represent a primitive form of the enzyme rather than a degradation product, is discussed briefly.
65 citations
TL;DR: Results demonstrate that the molybdenum cofactor isolated from formylmethanofuran dehydrogenase contains the phosphoric anhydride of molybdopterin and 5'‐GMP.
53 citations
TL;DR: In this article, a limited number of bacteria carry out denitrification, a process which releases fixed nitrogen to the atmosphere either as nitrous oxide or more usually as nitrogen gas.
51 citations
TL;DR: In this article, a combination of cyclic voltammetry, potentiometry and electron paramagnetic resonance (EPR) spectroscopy has been used to obtain structural, oxidation-reduction and compositional probes of the iron-molybdenum cofactor (FeMoco) from the MoFe protein of Azotobacter vinelandii nitrogenase.
13 citations