Journal ArticleDOI
The blood-brain barrier to proteins under normal and pathological conditions.
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A remarkable resistance to the development of post-traumatic brain edema was observed in sharks in which brain tissue appears also to be greatly resistant to the effects of radiation.About:
This article is published in Journal of the Neurological Sciences.The article was published on 1970-03-01. It has received 401 citations till now. The article focuses on the topics: Tight junction & Choroid plexus.read more
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Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.
Carlos Cordon-Cardo,James P. O'Brien,Dolors Casals,Lana Rittman-Grauer,June L. Biedler,Myron R. Melamed,Joseph R. Bertino +6 more
TL;DR: P-glycoprotein expression in capillary endothelium of brain and testes and not other tissues (i.e., kidney and placenta) may in part explain this phenomenon and could have important implications in cancer chemotherapy.
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Afferents to the rat caudoputamen studied with horseradish peroxidase. An evaluation of a retrograde neuroanatomical research method
TL;DR: The evidence presented suggests first, that the degree of localization at the injection site is compatible with approaching some problems in neuroanatomy; second, that anterograde transport of the marker protein does not appear to confound the interpretation of retrogradely labeled cell bodies; third, that many, though not all, afferent cell populations can be identified.
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Axonal uptake and retrograde transport of exogenous proteins in the hypoglossal nerve.
TL;DR: The results show that the hypoglossal neurones have the capacity to accumulate exogenous proteins after peripheral injection and this process must be a consequence of a fast retrograde axonal transport.
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Effect of focused ultrasound applied with an ultrasound contrast agent on the tight junctional integrity of the brain microvascular endothelium
TL;DR: This study provides the first direct evidence that ultrasound bursts combined with a gas contrast agent cause disassembling of the TJ molecular structure, leading to loss of the junctional barrier functions in brain microvessels.
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Iron metabolism in the CNS: implications for neurodegenerative diseases
TL;DR: A group of distinctive brain iron overload diseases known as 'neurodegeneration with brain iron accumulation' (NBIA) diseases, nine disease genes have been identified and understanding the early molecular pathophysiology of these diseases should aid insights into the role of iron and the design of specific therapeutic approaches.
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A formaldehyde-glutaraldehyde fixative of high osmolality for use in electron-microscopy
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Fine structural localization of a blood-brain barrier to exogenous peroxidase
TL;DR: These findings localize, at a fine structural level, a "barrier" to the passage of peroxidase at the endothelium of vessels in the cerebral cortex in mice, particularly with reference to a recent study in which similar techniques were applied to capillaries in heart and skeletal muscle.
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Junctions between intimately apposed cell membranes in the vertebrate brain
TL;DR: Endothelial and epithelial tight junctions occlude the interspaces between blood and parenchyma or cerebral ventricles, thereby constituting a structural basis for the blood-brain and blood-cerebrospinal fluid barriers.
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STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study
Guido Majno,G. E. Palade +1 more
TL;DR: The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope, and electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions.
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The ultrastructural basis of capillary permeability studied with peroxidase as a tracer
TL;DR: It is concluded that the endothelial cell junctions are most likely to be the morphological equivalent of the small pore system proposed by physiologists for the passage of small, lipid-insoluble molecules across the endothelium.