The branching programme of mouse lung development
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TLDR
This work presents the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates, and proposes that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations, which are themselvescontrolled by a more global master routine.Abstract:
Mammalian lungs are branched networks containing thousands to millions of airways arrayed in intricate patterns that are crucial for respiration. How such trees are generated during development, and how the developmental patterning information is encoded, have long fascinated biologists and mathematicians. However, models have been limited by a lack of information on the normal sequence and pattern of branching events. Here we present the complete three-dimensional branching pattern and lineage of the mouse bronchial tree, reconstructed from an analysis of hundreds of developmental intermediates. The branching process is remarkably stereotyped and elegant: the tree is generated by three geometrically simple local modes of branching used in three different orders throughout the lung. We propose that each mode of branching is controlled by a genetically encoded subroutine, a series of local patterning and morphogenesis operations, which are themselves controlled by a more global master routine. We show that this hierarchical and modular programme is genetically tractable, and it is ideally suited to encoding and evolving the complex networks of the lung and other branched organs.read more
Citations
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Preparing for the First Breath: Genetic and Cellular Mechanisms in Lung Development
TL;DR: Many gaps remain in knowledge, the filling of which is essential for understanding respiratory disorders, congenital defects in human neonates, and how the disruption of morphogenetic programs early in lung development can lead to deficiencies that persist throughout life.
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Alveolar progenitor and stem cells in lung development, renewal and cancer
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From cells to organs: building polarized tissue
David M. Bryant,Keith E. Mostov +1 more
TL;DR: This work discusses how conserved polarity complexes, signalling networks, transcription factors, membrane-trafficking pathways, mechanisms for forming lumens in tubes and other hollow structures, and transitions between different types of polarity, such as between epithelial and mesenchymal cells, are used in similar and iterative manners to build all tissues.
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Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function.
Brigid L.M. Hogan,Christina E. Barkauskas,Harold A. Chapman,Jonathan A. Epstein,Rajan Jain,Connie C. W. Hsia,Laura E. Niklason,Elizabeth A. Calle,Andrew V. Le,Scott H. Randell,Jason R. Rock,Melinda Snitow,Matthew F. Krummel,Barry R. Stripp,Thiennu H. Vu,Eric S. White,Jeffrey A. Whitsett,Edward E. Morrisey +17 more
TL;DR: The multiple stem/progenitor populations in different regions of the adult lung, the plasticity of their behavior in injury models, and molecular pathways that support homeostasis and repair are highlighted.
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Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling
TL;DR: It is argued that exploiting well-described model systems using both human airway epithelial cells and the pseudostratified epithelium of the genetically tractable mouse trachea will enable crucial discoveries regarding the pathogenesis of airway disease.
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