The Calcineurin B-Like Calcium Sensors CBL1 and CBL9 Together with Their Interacting Protein Kinase CIPK26 Regulate the Arabidopsis NADPH Oxidase RBOHF
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2,853 citations
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...ABA-activated SnRK2s also phosphorylate the plasma-membrane NADPH oxidase RbohF, which when phosphorylated generates O2 in the apoplastic space....
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...Phosphatidic acid contributes to ABA signaling by binding to and activating RbohD and RbohF (Zhang et al., 2009)....
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...Furthermore, ABA-triggered calcium signal can activate the CBL1/9-CIPK26 module to cause phosphorylation of effector proteins such as RbohF (Drerup et al., 2013)....
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1,462 citations
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...…at the guard cells with the ROS wave (Mittler and Blumwald, 2015) resulted in the opening of ROS-regulated Ca2+ channels that in turn induced the activation of RBOH by CIPK26 (Drerup et al., 2013), resulting in further biosynthesis of ROS and generating a positive feedback loop for stomata closure....
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...H2O2 generated by RBOH-SOD and/or arriving at the guard cells with the ROS wave (Mittler and Blumwald, 2015) resulted in the opening of ROS-regulated Ca2+ channels that in turn induced the activation of RBOH by CIPK26 (Drerup et al., 2013), resulting in further biosynthesis of ROS and generating a positive feedback loop for stomata closure....
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1,414 citations
Cites background from "The Calcineurin B-Like Calcium Sens..."
...In addition, a recent finding demonstrated that the activity of RBOHF is regulated by direct Ca 2+ binding to its EF-hands and Ca 2+ -dependent phosphorylation by CBL1/9–CIPK26 complexes (Drerup et al., 2013)....
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...…depend on various signalling components including protein phosphorylation , Ca 2+ , calcium-dependent protein kinases (CDPKs), and phospholipase Dα1 (PLDα1) (Lin et al., 2009; Monshausen et al., 2009; Zhang et al., 2009; Jakubowicz et al., 2010; Drerup et al., 2013; Dubiella et al., 2013)....
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...Unlike the mammalian counterpart , plant RBOHs have a cytosolic N-terminal extension comprised of two Ca 2+ -binding EF-hand motifs and phosphorylation target sites that are important for their activity (Kobayashi et al., 2007; Oda et al., 2010; Kimura et al., 2012; Drerup et al., 2013)....
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...(B) Binding of Ca 2+ to EF-hand motifs is required for activation of RBOHs (Ogasawara et al., 2008; Drerup et al., 2013)....
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...ABA is involved in a broad range of biological functions, and its integration with ROS has been revealed (Kwak et al., 2003; Sagi et al., 2004; Ma et al., 2012; Drerup et al., 2013)....
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687 citations
Cites background from "The Calcineurin B-Like Calcium Sens..."
...In addition, Ca2+ activates Ca2+-regulated protein kinases, such as CPKs or calcineurin-B-like proteininteracting protein kinases (CIPKs), which can phosphorylate RBOHs (Boudsocq and Sheen, 2013; Gao et al., 2013; Dubiella et al., 2013; Kimura et al., 2013; Drerup et al., 2013)....
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478 citations
Additional excerpts
...Drerup et al. (2013) OST1/SnRK2....
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References
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