The cancer genome atlas pan-cancer analysis project
Citations
6,095 citations
5,980 citations
Cites background from "The cancer genome atlas pan-cancer ..."
...To solve the imbalance between the tumor and normal data which can cause inefficiency in various differential analyses, we download the TCGA and GTEx gene expression data that are re-computed from raw RNA-Seq data by the UCSC Xena project based on a uniform pipeline (Figure 1)....
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...We introduce GEPIA (Gene Expression Profiling Interactive Analysis), a web-based tool to deliver fast and customizable functionalities based on TCGA and GTEx data....
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...In recent years, the Cancer Genome Atlas (TCGA) (3) and Genotype-Tissue Expression (GTEx) (4,5) projects produced RNA-Seq data for tens of thousands of cancer and non-cancer samples, providing an unprecedented opportunity for many related fields including cancer biology....
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...By using GEPIA, experimental biologists can easily explore the large TCGA and GTEx datasets, ask specific questions and test their hypotheses....
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...GEPIA is an interactive web application for gene expression analysis based on 9736 tumors and 8587 normal samples from the TCGA and the GTEx databases, using the output of a standard processing pipeline for RNA sequencing data....
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2,530 citations
2,512 citations
2,304 citations
Cites background or methods from "The cancer genome atlas pan-cancer ..."
...across cancer types and found a wide distribution of TMB across ~20–30 cancer types [28, 51, 54]....
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...We also analyzed whole-exome sequencing data from 35 studies, published as part of TCGA, examining a total of 8917 cancer specimens [54]....
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...TCGA data were obtained from public repositories [54]....
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References
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