The catechol estrogen, 4-hydroxyestrone, has tissue-specific estrogen actions.
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"The catechol estrogen, 4-hydroxyest..." refers background in this paper
...Although 2-OHE1 is the major circulating catechol metabolite and the level of 4-OHE1 is approximately 15–25% of 2-OHE1 (Adlercreutz et al. 1989), it is important to consider that individual tissues have the ability to metabolize estrogens and that circulating levels may not be reflective of the effects at an organ or tissue level ( Zhu & Conney 1998 )....
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...…and the level of 4-OHE1 is approximately 15–25% of 2-OHE1 (Adlercreutz et al. 1989), it is important to consider that individual tissues have the ability to metabolize estrogens and that circulating levels may not be reflective of the effects at an organ or tissue level (Zhu & Conney 1998)....
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"The catechol estrogen, 4-hydroxyest..." refers background in this paper
...Liehr & Ricci (1996) observed greater 4-hydroxylation in neoplastic breast tissue from breast cancer patients than in breast tissue from woman undergoing reduction mammoplasty....
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...Interestingly, 4-hydroxylase levels were also elevated in the normal breast tissue from the breast cancer patients (Liehr & Ricci 1996)....
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"The catechol estrogen, 4-hydroxyest..." refers background in this paper
...Ovariectomy resulted in the expected uterine and mammary gland atrophy while increasing body weight, serum cholesterol and indices of bone turnover (Wronski et al. 1986, 1988, Turner et al. 1987, Westerlind et al. 1993)....
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