The cell biology of ischemic renal injury
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TLDR
Most currently available data are pertinent to understanding the early events at the tubule cell level, and this information will necessarily comprise most of the review.About:
This article is published in Kidney International.The article was published on 1991-03-01 and is currently open access. It has received 346 citations till now.read more
Citations
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Pathophysiology of Acute Kidney Injury
TL;DR: The successful recovery from AKI depends on the degree to which repair processes ensue and these may be compromised in elderly or chronic kidney disease (CKD) patients, so targeting the extension phase of treatment with the greatest possible impact is suggested.
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Mitochondrial permeability transition: a common pathway to necrosis and apoptosis.
TL;DR: The MPT is a common pathway leading to both nec rotic and apoptotic cell death after ischemia/reperfusion, and the balance between ATP depletion after the MPT and ATP generation by glycolysis determines whether the fate of cells will be apoptotic or necrotic death.
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Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models
TL;DR: In vivo analysis revealed that mitochondrial fragmentation also occurred in proximal tubular cells in mice during renal ischemia/reperfusion and cisplatin-induced nephrotoxicity, and was identified as what is believed to be a novel mechanism contributing to mitochondrial damage and apoptosis in vivo in mouse models of disease.
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Rhabdomyolysis and myohemoglobinuric acute renal failure.
TL;DR: How muscle necrosis can negatively impact the kidney, potentially culminating in tubular necrosis and ARF is discussed, to review current and possible future pharmacologic approaches for the management of this dramatic and often life threatening "myo-renal syndrome".
Journal Article
Ischemia-reperfusion injury.
A Seekamp,P A Ward +1 more
TL;DR: In this article, a rat hind limb following ischemia-reperfusion of the hind limb resulted in increased vascular permeability and hemorrhage in skeletal muscle as well as distant organ injury.
References
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Book
Principles of Biochemistry
TL;DR: The third edition, coming ten years after the first, emphasizes both the flowering of biochemical research and the prodigious effort by busy teachers and scientists to keep up to date this popular text and reference.
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Oxygen-derived free radicals in postischemic tissue injury.
TL;DR: It is now clear that oxygen-derived free radicals play an important part in several models of experimentally induced reperfusion injury, and Dysfunction induced by free radicals may be a major component of ischemic diseases of the heart, bowel, liver, kidney, and brain.
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The heat-shock response
TL;DR: A comparison of different Organisms and Stages of Development and Heat-Induced Lethality and Thermotolerance and the role of RNA Processing are presented.
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The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen.
Alberto Boveris,Britton Chance +1 more
TL;DR: It is postulated that in addition to the well-known flavin reaction, formation of H( 2)O(2) may be due to interaction with an energy-dependent component of the respiratory chain at the cytochrome b level.
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Intracellular calcium homeostasis
TL;DR: The ctl+ -Transporting Systems of Mitochondria, an analysis of the transport systems of Mit mitochondria, concludes that the systems are efficient and effective at transporting large volumes of material.