Open AccessJournal Article
The clinical course of smell and taste loss in COVID-19 hospitalized patients
Athanasia Printza,Michael Katotomichelakis,Symeon Metallidis,Periklis Panagopoulos,A Sarafidou,Vasilis Petrakis,Jannis Constantinidis +6 more
Reads0
Chats0
TLDR
In this paper, the authors investigated the prevalence of smell and/or taste loss and the clinical characteristics and recovery in a comprehensive cohort of consecutive patients treated by two COVID-19 reference hospitals and evaluated late persistence of hyposmia.Abstract:
Background Recent studies have demonstrated an association between a new onset of smell or taste loss and COVID-19. We investigated the prevalence of smell and/or taste loss and the clinical characteristics and recovery in a comprehensive cohort of consecutive patients treated by two COVID-19 reference hospitals and evaluated late persistence of hyposmia. Methods A retrospective observational questionnaire study was conducted. All consecutive RT-PCR diagnosed patients who had been hospitalized in March-April 2020 in the COVID-19 care wards were contacted, excluding patients with cognitive disorders and severe deconditioning. The patients responded to a survey about the loss of smell and taste, nasal blockage, and rhinorrhea, rated the symptoms' severity from 0 to 4, and reported the recovery of smell and taste with time. Demographic and clinical characteristics were recorded. Results We contacted 117 patients. Ninety responded to the questionnaire; 38.9 % of them reported olfactory and 36.66 % gustatory disorders during their disease. Smell loss prior to other symptoms was reported by 42.86 %, and severe hyposmia/anosmia by 74.28 % of the hyposmic. Among the non-ICU treated patients, 43.75 % reported hyposmia. Only 8.89 % had nasal blockage, and 6.66 % rhinorrhea. Most of the patients (85.71 %) recovered their sense of smell in 3-61 days (median: 17; IQR: 24), but 8.57 % had persistent hyposmia. For one out of four, the olfactory loss lasted longer than a month. Conclusion Smell and taste loss are highly prevalent and early symptoms in hospitalized COVID-19 patients. The great majority recover their smell, but nearly one out of ten have not recovered in two months. HIPPOKRATIA 2020, 24(2): 66-71.read more
Citations
More filters
Journal ArticleDOI
Post-COVID-19 Syndrome: The Persistent Symptoms at the Post-viral Stage of the Disease. A Systematic Review of the Current Data
TL;DR: In this article, the authors did a systematic review on PubMed, Web of Science, EMBASE, and Google Scholar from database inception to February 15, 2021, for studies on long-term COVID-19 symptoms.
Journal ArticleDOI
Prognosis and persistence of smell and taste dysfunction in patients with covid-19: meta-analysis with parametric cure modelling of recovery curves
Benjamin K.J. Tan,Ruobing Han,Joseph J. Zhao,N. C. K. Tan,Emrick Sen Hui Quah,C. Tan,Yiong Huak Chan,Neville Wei Yang Teo,Tze Choong Charn,Anna See,Shuhui Xu,Nikita Chapurin,Ramesh Chandra,Naweed I. Chowdhury,Rafal Butowt,Christopher S. von Bartheld,B. Nirmal Kumar,Claire Hopkins,Song Tar Toh +18 more
TL;DR: In this paper , a systematic review and meta-analysis was performed to explore unadjusted associations of prognostic factors associated with recovery of smell and taste in patients with covid-19.
Journal ArticleDOI
Incomplete Systemic Recovery and Metabolic Phenoreversion in Post-Acute-Phase Nonhospitalized COVID-19 Patients: Implications for Assessment of Post-Acute COVID-19 Syndrome.
Elaine Holmes,Elaine Holmes,Julien Wist,Julien Wist,Reika Masuda,Samantha Lodge,Philipp Nitschke,Torben Kimhofer,Ruey Leng Loo,Sofina Begum,Berin A. Boughton,Rongchang Yang,Aude-Claire Morillon,Sung Tong Chin,Drew Hall,Monique Ryan,Sze-How Bong,Dale W. Edgar,Dale W. Edgar,John C. Lindon,Toby Richards,Bu B. Yeap,Sven Pettersson,Sven Pettersson,Manfred Spraul,Hartmut Schaefer,Nathan G. Lawler,Nicola Gray,Luke Whiley,Jeremy K. Nicholson,Jeremy K. Nicholson +30 more
TL;DR: In this paper, a multivariate metabotyping approach was used to assess the functional recovery of non-hospitalized COVID-19 patients and the possible biochemical sequelae of "Post-Acute CoV-19 Syndrome", colloquially known as long-COVID.
Journal ArticleDOI
More Than 100 Persistent Symptoms of SARS-CoV-2 (Long COVID): A Scoping Review.
TL;DR: In this article, a scoping review of the literature was conducted using the Arksey and O'Malley framework to aggregate type and prevalence of symptoms in people with long COVID.
Journal ArticleDOI
Smell and Taste Loss Recovery Time in COVID-19 Patients and Disease Severity.
Athanasia Printza,Mihalis Katotomichelakis,Konstantinos Valsamidis,Symeon Metallidis,Periklis Panagopoulos,Maria Panopoulou,Vasilis Petrakis,Jannis Constantinidis +7 more
TL;DR: A significant proportion of people infected with SARS-CoV-2 report a new onset of smell or taste loss as discussed by the authors, but the duration of the chemosensory impairment and predictive factors of recovery are still unclear.
References
More filters
Journal ArticleDOI
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
Journal ArticleDOI
Olfactory and gustatory dysfunctions as a clinical presentation of mild-to-moderate forms of the coronavirus disease (COVID-19): a multicenter European study.
Jerome R. Lechien,Carlos M. Chiesa-Estomba,Daniele R De Siati,Mihaela Horoi,Serge D Le Bon,Alexandra Rodriguez,Didier Dequanter,Serge Blecic,Fahd El Afia,Lea Distinguin,Younes Chekkoury-Idrissi,Stéphane Hans,Irene Lopez Delgado,Christian Calvo-Henriquez,Philippe Lavigne,Chiara Falanga,Maria Rosaria Barillari,Giovanni Cammaroto,Mohamad Khalife,Pierre Leich,Christel Souchay,Camelia Rossi,Fabrice Journe,Julien Hsieh,Myriam Edjlali,Myriam Edjlali,Robert Carlier,Laurence Ris,Andrea Lovato,Cosimo de Filippis,Frédérique Coppée,Nicolas Fakhry,Tareck Ayad,Sven Saussez +33 more
TL;DR: Olfactory and gustatory disorders are prevalent symptoms in European CO VID-19 patients, who may not have nasal symptoms, and the sudden anosmia or ageusia need to be recognized by the international scientific community as important symptoms of the COVID-19 infection.
Journal ArticleDOI
Spread of SARS-CoV-2 in the Icelandic Population.
Daniel F. Gudbjartsson,Agnar Helgason,Hakon Jonsson,Olafur T. Magnusson,Páll Melsted,Gudmundur L. Norddahl,Jona Saemundsdottir,Asgeir Sigurdsson,Patrick Sulem,Arna B Agustsdottir,Berglind Eiriksdottir,Run Fridriksdottir,Elisabet E Gardarsdottir,Gudmundur Georgsson,Olafia S Gretarsdottir,Kjartan R Gudmundsson,Thora R Gunnarsdottir,Arnaldur Gylfason,Hilma Holm,Brynjar O. Jensson,Aslaug Jonasdottir,Frosti Jonsson,Kamilla S Josefsdottir,Thordur Kristjansson,Droplaug N Magnusdottir,Louise le Roux,Gudrun Sigmundsdottir,Gardar Sveinbjornsson,Kristin E Sveinsdottir,Maney Sveinsdottir,Emil A Thorarensen,Bjarni Thorbjornsson,Arthur Löve,Gisli Masson,Ingileif Jonsdottir,Alma D. Möller,Thorolfur Gudnason,Karl G. Kristinsson,Unnur Thorsteinsdottir,Kari Stefansson +39 more
TL;DR: In a population-based study in Iceland, children under 10 years of age and females had a lower incidence of SARS-CoV-2 infection than adolescents or adults and males and the proportion of infected participants identified through population screening remained stable for the 20-day duration of screening.
Journal ArticleDOI
Self-reported Olfactory and Taste Disorders in Patients With Severe Acute Respiratory Coronavirus 2 Infection: A Cross-sectional Study.
Andrea Giacomelli,Laura Pezzati,Federico Conti,Dario Bernacchia,Matteo Siano,Letizia Oreni,Stefano Rusconi,Cristina Gervasoni,Anna Lisa Ridolfo,Giuliano Rizzardini,Spinello Antinori,Massimo Galli +11 more
TL;DR: Survey shows that OTDs are fairly frequent in patients with SARS-CoV-2 infection and may precede the onset of full-blown clinical disease, which could explain the underlying pathogenetic mechanism of taste and olfactory disorders in SARS.
Journal ArticleDOI
Association of chemosensory dysfunction and COVID-19 in patients presenting with influenza-like symptoms.
TL;DR: Understanding the timing and association of smell/taste loss in COVID‐19 may help facilitate screening and early isolation of cases.