The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy
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...[26] indicate that doxorubicin treatment affects mitochondrial gene expression....
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"The CO/HO system reverses inhibitio..." refers background in this paper
...Moreover, CO establishes mitochondrial oxidant activation of Akt1, which promotes NRF-1 phosphorylation/nuclear translocation, Tfam gene expression, and mtDNA replication (17), and Akt signaling is influenced by cGMP-dependent PI3K activation (41, 42), which confers a potent antiapoptotic effect by direct phosphorylation and inactivation of proapoptotic proteins including caspase-3 (43)....
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...Despite its efficacy, the drug is associated therapeutically with a dilated cardiomyopathy (1), and more than a quarter of patients who receive DOX develop significant cardiac morbidity (2)....
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...Carbon monoxide actuates O(2)-limited heme degradation in the rat brain....
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"The CO/HO system reverses inhibitio..." refers background in this paper
...Upon release by mitochondria, AIF binds to cyclophilin A to form an active cytoplasmic DNase that translocates to the nucleus and participates in chromatinolysis (21, 35, 36)....
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"The CO/HO system reverses inhibitio..." refers background in this paper
..., that released by mitochondria, into the antioxidant biliverdin (12)....
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