The combination matters--distinct impact of lifestyle factors on sperm quality: a study on semen analysis of 1683 patients according to MSOME criteria.
TL;DR: Combinations of adverse lifestyle factors could have a detrimental impact on sperm, not only in terms of motility and sperm count but also in Terms of sperm head vacuolization.
Abstract: Background
Poor sperm quality can negatively affect embryonic development and IVF outcome. This study is aimed at investigating the influence of various lifestyle factors on semen quality according to MSOME (motile sperm organelle morphology examination) criteria.
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TL;DR: It is suggested that greater focus on collection of DNA fragmentation and progressive motility in a clinical setting may lead to better patient outcomes during fertility treatments of aging couples, even though sperm concentration did not decline with increasing male age.
257 citations
TL;DR: Results showed that alcohol intake has a detrimental effect on semen volume and normal morphology, and studies evaluating the effect of changes on semen parameters on the reproductive outcomes are needed in advance of providing recommendations regarding alcohol intake other than the advice to avoid heavy alcohol drinking.
Abstract: Alcohol consumption is widespread in the Western world. Some studies have suggested a negative association between alcohol intake and semen quality although others have not confirmed this. MEDLINE and Embase were searched using ‘alcohol intake' OR ‘alcohol consumption' OR ‘alcohol drinking' OR ‘lifestyle' combined with ‘semen quality' OR ‘sperm quality' OR ‘sperm volume' OR ‘sperm concentration' OR ‘sperm motility' for full-length observational articles, published in English. Reference lists of retrieved articles were searched for other pertinent studies. Main outcome measures were sperm parameters, if provided as means (standard deviation or standard error) or as medians (interquartile range). Fifteen cross-sectional studies were included, with 16,395 men enrolled. Main results showed that alcohol intake has a detrimental effect on semen volume (pooled estimate for no/low alcohol consumption 0.25 ml, 95% CI, 0.07 to 0.42) and normal morphology (1.87%, 95% CI, 0.86 to 2.88%). The difference was more marked when comparing occasional versus daily consumers, rather than never versus occasional, suggesting a moderate consumption did not adversely affect semen parameters. Hence, studies evaluating the effect of changes on semen parameters on the reproductive outcomes are needed in advance of providing recommendations regarding alcohol intake other than the advice to avoid heavy alcohol drinking.
125 citations
TL;DR: Severe male factor impairs early embryonic competence in terms of fertilization rate and developmental potential, however, the euploidy rate and implantation potential of the obtained blastocysts are independent from sperm quality.
96 citations
TL;DR: The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function, and well-designed studies are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.
Abstract: Semen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy. A systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included. We retrieved 28 papers reporting observational information on coffee/caffeine intake and reproductive outcomes. Overall, they included 19,967 men. 1. Semen parameters did not seem affected by caffeine intake, at least caffeine from coffee, tea and cocoa drinks, in most studies. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. 2. As regards sperm DNA defects, caffeine intake seemed associated with aneuploidy and DNA breaks, but not with other markers of DNA damage. 3. Finally, male coffee drinking was associated to prolonged time to pregnancy in some, but not all, studies. The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Evidence from epidemiological studies on semen parameters and fertility is however inconsistent and inconclusive. Well-designed studies with predefined criteria for semen analysis, subject selection, and life style habits definition, are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.
90 citations
Cites background from "The combination matters--distinct i..."
...Wogatzky, 2012 [39] Mean (SD) Mean (SD) Mean (SD) Mean (SD)...
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...Wogatzky, 2012 [39] Not estimated Cups of coffee per day 204 men out of 1321 drinking coffee had an intake of more than 3 cups of coffee per day....
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...Wogatzky, 2012 [39] Austria 1683 Cross-sectional Fertility clinic: infertile couples Semen variables 40....
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TL;DR: Smoking, coffee/cola/fried foods consumption, and the effects of environmental/sociopsychobehavioral factors act on semen quality are found to be significantly associated with semen quality from the baseline investigation.
61 citations
Cites result from "The combination matters--distinct i..."
...But in other studies, decreased semen quality or its tendency was also observed.(55,56,63) Similar result was found for cola consumption in this study, but lower semen volume and lower total sperm count were found in cola consumers....
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References
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Journal Article•
TL;DR: The results indicated that mental stress negatively affected semen quality, with increase in SOD activities led to poor quality of semen parameters.
Abstract: Background & objectives: Mental stress, which is responsible for various disorders, is one of the most important medical and social problems. It is reported that mental stress causes abnormality in sperm quality. Most of the previous investigations done to study the association between mental stress and infertility were carried out with infertile men. Infertility itself and/or its therapy may lead to stress. Further, most studies investigating the association between psychological stress and semen quality have lacked information on biochemical parameters. In the present study, we investigated the effect of mental stress due to final exams on two important antioxidant enzymes of the seminal plasma, superoxide dismutase (SOD) and catalase in normal healthy medical students. Methods: Semen samples were collected from 27 healthy male volunteers, who were third semester students of a medical school, just before (stress period) and 10.19±0.83 wk after (non-stress period) the final examinations. Psychological stress of participants was measured by the State Trait Anxiety Inventory. After standard semen analysis, semen samples were centrifuged at 10,000 x g for 15 min. Superoxide dismutase (SOD) and catalase activities were measured in the seminal plasma.
47 citations
"The combination matters--distinct i..." refers background in this paper
...Although it is commonly accepted from the animal model systems that stress is detrimental for fertility, the outcome of studies regarding humans is quite controversial [40-43]....
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TL;DR: The lifestyle of the subject has little, if any, impact on semen quality, at least within the limits recorded in the present study, and the reported average ejaculation frequency was significantly positively correlated to the motility of the sperm.
43 citations
TL;DR: A significant inverse correlation between the BMI and the sperm parameters was revealed and total sperm count and sperm motility in overweight and obese men were significantly lower than men with normal BMI too.
Abstract: Overweight and obese men have been reported to have lower sperm quality. The aim of this study was to evaluate, whether body mass index (BMI) is related to changes in semen parameters. In a cross-sectional study, sperm parameters were reviewed in 852 normal, healthy men, of reproductive age (25-50). BMI was divided into four groups: underweight, normal, overweight and obese. Sperm concentration of overweight and obese men were 63 and 62, respectively, which were lower than subjects with normal BMI (71). Total sperm count and sperm motility in overweight and obese men were significantly lower than men with normal BMI too. Sperm morphology in study groups was similar. The results revealed a significant inverse correlation between the BMI and the sperm parameters.
41 citations
"The combination matters--distinct i..." refers background in this paper
...Over- and underweight is seen as a risk factor for low sperm quality [2,28-30]....
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...Among the individual factors which are considered to increase or decrease sperm quality in humans as defined by the Kruger or WHO (World Health Organization) criteria [1-5] are environment, occupation, nutrition, stimulants, ejaculation frequency and lifestyle choices....
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TL;DR: The significant positive correlation and absence of differences between two sperm samples evaluated after a time interval with respect to normal morphology and LNV spermatozoa indicated that MSOME seems reliable (at least for these two specific sperm forms) for analyzing semen.
Abstract: Background: Although the motile sperm organelle morphology examination (MSOME) was developed only as a selection criterion, its application as a method for classifying sperm morphology may represent an improvement in evaluation of semen quality, with potential clinical repercussions. The present study aimed to evaluate individual variations in the motile sperm organelle morphology examination (MSOME) analysis after a time interval. Methods: Two semen samples were obtained from 240 men from an unselected group of couples undergoing infertility investigation and treatment. Mean time interval between the two semen evaluations was 119 +/- 102 days. No clinical or surgical treatment was realized between the two observations. Spermatozoa were analyzed at greater than or equal to 8400× magnification by inverted microscope equipped with DIC/Nomarski differential interference contrast optics. At least 200 motile spermatozoa per semen sample were evaluated and percentages of normal spermatozoa and spermatozoa with large nuclear vacuoles (LNV/one or more vacuoles occupying >50% of the sperm nuclear area) were determined. A spermatozoon was classified as morphologically normal when it exhibited a normal nucleus (smooth, symmetric and oval nucleus, width 3.28 +/- 0.20 μm, length 4.75 +/- 0.20 μm/absence of vacuoles occupying >4% of nuclear area) as well as acrosome, post-acrosomal lamina, neck and tail, besides not presenting cytoplasm around the head. One examiner, blinded to subject identity, performed the entire study. Results: Mean percentages of morphologically normal and LNV spermatozoa were identical in the two MSOME analyses (1.6 +/- 2.2% vs. 1.6 +/- 2.1% P = 0.83 and 25.2 +/- 19.2% vs. 26.1 +/- 19.0% P = 0.31, respectively). Regression analysis between the two samples revealed significant positive correlation for morphologically normal and for LNV spermatozoa (r = 0.57 95% CI:0.47-0.65 P < 0.0001 and r = 0.50 95% CI:0.38-0.58 P < 0.0001, respectively). Conclusions: The significant positive correlation and absence of differences between two sperm samples evaluated after a time interval with respect to normal morphology and LNV spermatozoa indicated that MSOME seems reliable (at least for these two specific sperm forms) for analyzing semen. The present result supports the future use of MSOME as a routine method for semen analysis.
38 citations
"The combination matters--distinct i..." refers background in this paper
...Therefore, MSOME has been considered as representing an improvement in the evaluation of semen quality [19,20]....
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TL;DR: The associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle are described and no associations were found between any semen characteristic or sexual hormones and any job strain variable.
Abstract: BACKGROUND: Job strain, defined as high job demands and low job control, has not previously been explored as a possible determinant of male fertility. We collected prospective data on job strain among men, and describe the associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle. METHODS: Danish couples (N = 399) who were trying to become pregnant for the first time were followed for up to 6 menstrual periods. All men collected semen samples, and a blood sample was drawn from both partners. Job demand and job control were measured by a self-administered questionnaire at entry, and in each cycle the participants recorded changes in job control or job demand during the previous 30 days. RESULTS: In adjusted analyses, no associations were found between any semen characteristic or sexual hormones and any job strain variable. The odds for pregnancy were not associated with job strain. CONCLUSIONS: Psychologic job strain encountered in normal jobs in Denmark does not seem to affect male reproductive function. (Less)
35 citations