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Journal ArticleDOI

The combination matters--distinct impact of lifestyle factors on sperm quality: a study on semen analysis of 1683 patients according to MSOME criteria.

TL;DR: Combinations of adverse lifestyle factors could have a detrimental impact on sperm, not only in terms of motility and sperm count but also in Terms of sperm head vacuolization.
Abstract: Background Poor sperm quality can negatively affect embryonic development and IVF outcome. This study is aimed at investigating the influence of various lifestyle factors on semen quality according to MSOME (motile sperm organelle morphology examination) criteria.

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Citations
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Journal ArticleDOI
TL;DR: It is suggested that greater focus on collection of DNA fragmentation and progressive motility in a clinical setting may lead to better patient outcomes during fertility treatments of aging couples, even though sperm concentration did not decline with increasing male age.

257 citations

Journal ArticleDOI
TL;DR: Results showed that alcohol intake has a detrimental effect on semen volume and normal morphology, and studies evaluating the effect of changes on semen parameters on the reproductive outcomes are needed in advance of providing recommendations regarding alcohol intake other than the advice to avoid heavy alcohol drinking.
Abstract: Alcohol consumption is widespread in the Western world. Some studies have suggested a negative association between alcohol intake and semen quality although others have not confirmed this. MEDLINE and Embase were searched using ‘alcohol intake' OR ‘alcohol consumption' OR ‘alcohol drinking' OR ‘lifestyle' combined with ‘semen quality' OR ‘sperm quality' OR ‘sperm volume' OR ‘sperm concentration' OR ‘sperm motility' for full-length observational articles, published in English. Reference lists of retrieved articles were searched for other pertinent studies. Main outcome measures were sperm parameters, if provided as means (standard deviation or standard error) or as medians (interquartile range). Fifteen cross-sectional studies were included, with 16,395 men enrolled. Main results showed that alcohol intake has a detrimental effect on semen volume (pooled estimate for no/low alcohol consumption 0.25 ml, 95% CI, 0.07 to 0.42) and normal morphology (1.87%, 95% CI, 0.86 to 2.88%). The difference was more marked when comparing occasional versus daily consumers, rather than never versus occasional, suggesting a moderate consumption did not adversely affect semen parameters. Hence, studies evaluating the effect of changes on semen parameters on the reproductive outcomes are needed in advance of providing recommendations regarding alcohol intake other than the advice to avoid heavy alcohol drinking.

125 citations

Journal ArticleDOI
TL;DR: Severe male factor impairs early embryonic competence in terms of fertilization rate and developmental potential, however, the euploidy rate and implantation potential of the obtained blastocysts are independent from sperm quality.

96 citations

Journal ArticleDOI
TL;DR: The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function, and well-designed studies are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.
Abstract: Semen quality, a predictor of male fertility, has been suggested declining worldwide. Among other life style factors, male coffee/caffeine consumption was hypothesized to influence semen parameters, but also sperm DNA integrity. To summarize available evidence, we performed a systematic review of observational studies on the relation between coffee/caffeine intake and parameters of male fertility including sperm ploidy, sperm DNA integrity, semen quality and time to pregnancy. A systematic literature search was performed up to November 2016 (MEDLINE and EMBASE). We included all observational papers that reported the relation between male coffee/caffeine intake and reproductive outcomes: 1. semen parameters, 2. sperm DNA characteristics, 3. fecundability. All pertinent reports were retrieved and the relative reference lists were systematically searched in order to identify any potential additional studies that could be included. We retrieved 28 papers reporting observational information on coffee/caffeine intake and reproductive outcomes. Overall, they included 19,967 men. 1. Semen parameters did not seem affected by caffeine intake, at least caffeine from coffee, tea and cocoa drinks, in most studies. Conversely, other contributions suggested a negative effect of cola-containing beverages and caffeine-containing soft drinks on semen volume, count and concentration. 2. As regards sperm DNA defects, caffeine intake seemed associated with aneuploidy and DNA breaks, but not with other markers of DNA damage. 3. Finally, male coffee drinking was associated to prolonged time to pregnancy in some, but not all, studies. The literature suggests that caffeine intake, possibly through sperm DNA damage, may negatively affect male reproductive function. Evidence from epidemiological studies on semen parameters and fertility is however inconsistent and inconclusive. Well-designed studies with predefined criteria for semen analysis, subject selection, and life style habits definition, are essential to reach a consistent evidence on the effect of caffeine on semen parameters and male fertility.

90 citations


Cites background from "The combination matters--distinct i..."

  • ...Wogatzky, 2012 [39] Mean (SD) Mean (SD) Mean (SD) Mean (SD)...

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  • ...Wogatzky, 2012 [39] Not estimated Cups of coffee per day 204 men out of 1321 drinking coffee had an intake of more than 3 cups of coffee per day....

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  • ...Wogatzky, 2012 [39] Austria 1683 Cross-sectional Fertility clinic: infertile couples Semen variables 40....

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Journal ArticleDOI
01 Jul 2015-Medicine
TL;DR: Smoking, coffee/cola/fried foods consumption, and the effects of environmental/sociopsychobehavioral factors act on semen quality are found to be significantly associated with semen quality from the baseline investigation.

61 citations


Cites result from "The combination matters--distinct i..."

  • ...But in other studies, decreased semen quality or its tendency was also observed.(55,56,63) Similar result was found for cola consumption in this study, but lower semen volume and lower total sperm count were found in cola consumers....

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References
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Journal ArticleDOI
TL;DR: It is concluded that smoking has a negative impact on sperm DNA and RNA abnormalities that is accentuated in heavy smokers compared with light smokers.
Abstract: Summary This study aimed to assess sperm DNA and RNA abnormalities in fertile and oligoasthenoteratozoospermic (OAT) smokers. In all, 140 subjects were included and classified into fertile nonsmokers, fertile smokers, OAT nonsmokers and OAT smokers. They were subjected to history taking, clinical examination, semen analysis, assessment of sperm DNA and RNA abnormalities. The results showed that an increased percentage of abnormal sperm DNA and RNA was demonstrated in fertile smokers compared with fertile nonsmokers and in OAT smokers compared with OAT nonsmokers. Increased percentage of severe, moderate sperm DNA and RNA damage was demonstrated in fertile heavy smokers compared with fertile light smokers and in OAT heavy smokers compared with OAT light smokers. It is concluded that smoking has a negative impact on sperm DNA and RNA abnormalities that is accentuated in heavy smokers compared with light smokers.

17 citations


"The combination matters--distinct i..." refers background in this paper

  • ...Several publications indicate adverse effects of smoking on sperm parameters [1,37-39]....

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Journal ArticleDOI

3 citations


"The combination matters--distinct i..." refers background in this paper

  • ...Even though the origin of vacuoles is still not completely understood and it has been fiercely discussed whether those vacuoles originate from a natural process or, more likely, from pathological (stress) situations during spermatogenesis [21,22], a study by Brassesco and colleagues demonstrated that sperm vacuolization improves after antioxidant therapy [46]....

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Can robust increase sperm count?

The negative impact of age, BMI and coffee intake on sperm quality could be compensated if patients had a high ejaculation frequency and shorter periods of sexual abstinence. Combinations of adverse lifestyle factors could have a detrimental impact on sperm, not only in terms of motility and sperm count but also in terms of sperm head vacuolization.