The coordination of nuclear and mitochondrial communication during aging and calorie restriction.
Reads0
Chats0
TLDR
This review will focus on PGC-1alpha, SIRT1, AMPK and mTOR and discuss how these proteins regulate mitochondrial function and their potential involvement in aging, calorie restriction and age-related disease.About:
This article is published in Ageing Research Reviews.The article was published on 2009-03-27 and is currently open access. It has received 200 citations till now. The article focuses on the topics: mitochondrial fusion & DNAJA3.read more
Citations
More filters
Journal Article
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. [Erratum: 2004 Sept. 23, v. 431, no. 7007, p. 485.]
Sung Hee Um,Francesca Frigerio,Mitsuhiro Watanabe,Frédéric Picard,Manel Joaquin,Melanie Sticker,Stefano Fumagalli,Peter R. Allegrini,Sara C. Kozma,Johan Auwerx +9 more
TL;DR: In this article, S6K1-deficient mice are protected against obesity owing to enhanced β-oxidation, but on a high fat diet, levels of glucose and free fatty acids still rise in S6k1-dependent mice, resulting in insulin receptor desensitization.
Journal ArticleDOI
Telomere dysfunction induces metabolic and mitochondrial compromise
Ergiin Sahin,Simona Colla,Marc Liesa,Javid Moslehi,Florian L. Muller,Mira Guo,Marcus P. Cooper,Darrell N. Kotton,Attila J. Fabian,Carl Walkey,Richard S. Maser,Giovanni Tonon,Friedrich Foerster,Robert Xiong,Y. Alan Wang,Sachet A. Shukla,Mariela Jaskelioff,Eric S. Martin,Timothy P. Heffernan,Alexei Protopopov,Elena Ivanova,John E. Mahoney,Maria Kost-Alimova,Samuel R. Perry,Roderick T. Bronson,Ronglih Liao,Richard C. Mulligan,Orian S. Shirihai,Lynda Chin,Ronald A. DePinho +29 more
TL;DR: It is shown that enforced Tert or PGC-1α expression or germline deletion of p53 substantially restores PGC network expression, mitochondrial respiration, cardiac function and gluconeogenesis in the setting of telomere dysfunction.
Journal ArticleDOI
The role of mitochondria in aging
Ana Bratic,Nils-Göran Larsson +1 more
TL;DR: The caveats of the traditional mitochondrial free radical theory of aging are discussed and other possible mechanisms, including insulin/IGF-1 signaling and the target of rapamycin pathways, that underlie the central role of mitochondria in the aging process are highlighted.
Journal ArticleDOI
AMPK and SIRT1: a long-standing partnership?
TL;DR: The evidence that AMPK and SIRT1 both regulate each other and share many common target molecules is examined and the possibility that their dysregulation predisposes to disorders such as type 2 diabetes and atherosclerotic cardiovascular disease is discussed.
Journal ArticleDOI
How increased oxidative stress promotes longevity and metabolic health: The concept of mitochondrial hormesis (mitohormesis)
Michael Ristow,Kim Zarse +1 more
TL;DR: It is indicated that ROS are essential signaling molecules which are required to promote health and longevity and the concept of mitohormesis provides a common mechanistic denominator for the physiological effects of physical exercise, reduced calorie uptake, glucose restriction, and possibly beyond.
References
More filters
Journal ArticleDOI
Oxidants, oxidative stress and the biology of ageing.
Toren Finkel,Nikki J. Holbrook +1 more
TL;DR: Evidence that the appropriate and inappropriate production of oxidants, together with the ability of organisms to respond to oxidative stress, is intricately connected to ageing and life span is reviewed.
Journal ArticleDOI
PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
Vamsi K. Mootha,Cecilia M. Lindgren,Cecilia M. Lindgren,Karl-Fredrik Eriksson,Aravind Subramanian,Smita Sihag,J. Lehar,Pere Puigserver,Emma Carlsson,Martin Ridderstråle,Esa Laurila,Nicholas E. Houstis,Mark J. Daly,Nick Patterson,Jill P. Mesirov,Todd R. Golub,Todd R. Golub,Pablo Tamayo,Bruce M. Spiegelman,Eric S. Lander,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,David Altshuler,Leif Groop +24 more
TL;DR: An analytical strategy is introduced, Gene Set Enrichment Analysis, designed to detect modest but coordinate changes in the expression of groups of functionally related genes, which identifies a set of genes involved in oxidative phosphorylation whose expression is coordinately decreased in human diabetic muscle.
Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
TOR signaling in growth and metabolism.
TL;DR: The physiological consequences of mammalianTORC1 dysregulation suggest that inhibitors of mammalian TOR may be useful in the treatment of cancer, cardiovascular disease, autoimmunity, and metabolic disorders.
Journal ArticleDOI
Resveratrol improves health and survival of mice on a high-calorie diet
Joseph A. Baur,Kevin J. Pearson,Nathaniel O Price,Hamish A. Jamieson,Carles Lerin,Avash Kalra,Vinayakumar Prabhu,Joanne S. Allard,Guillermo López-Lluch,Kaitlyn N. Lewis,Paul J. Pistell,Suresh Poosala,Kevin G. Becker,Olivier Boss,Dana M. Gwinn,Mingyi Wang,Sharan Ramaswamy,Kenneth W. Fishbein,Richard G. Spencer,Edward G. Lakatta,David G. Le Couteur,Reuben J. Shaw,Plácido Navas,Pere Puigserver,Donald K. Ingram,Rafael de Cabo,David A. Sinclair +26 more
TL;DR: It is shown that resveratrol shifts the physiology of middle-aged mice on a high-calorie diet towards that of mice onA standard diet and significantly increases their survival and point to new approaches for treating obesity-related disorders and diseases of ageing.