The core promoter: At the heart of gene expression.
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128 citations
Cites background from "The core promoter: At the heart of ..."
...At the core promoter, located approximately ±50 bp relative to the TSS, basal TFs cooperate with conserved DNA sequence motifs to orchestrate recruitment of the RNA polymerase (RNAP) (1, 3)....
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117 citations
Cites background from "The core promoter: At the heart of ..."
...The initiation of Pol II transcription is mediated by a stretch of DNA known as the core promoter (for reviews, see Smale and Kadonaga 2003; Goodrich and Tjian 2010; Kadonaga 2012; Lenhard et al. 2012; Danino et al. 2015; Roy and Singer 2015)....
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116 citations
Cites background from "The core promoter: At the heart of ..."
...The core promoter directs accurate transcription initiation when bound by some basal TFs, and provides little or no basal expression level [14 ,15]....
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81 citations
71 citations
Cites background from "The core promoter: At the heart of ..."
...Although it was previously believed that the core promoter is a universal component that works in a similar mechanism for all protein-coding genes, it is nowadays established that core promoters differ in their architecture and function.(3,4,7-10) Moreover, distinct core promoter compositions were demonstrated to result in diverse transcriptional outputs....
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References
11,528 citations
Additional excerpts
...Insights are gained from studies of specific genes and gene networks [13-15], as well as from genome-wide studies [11, 16] utilizing methodologies such as PEAT [17], 5' RACE [18], CAGE [19], FAIRE-seq [20], ChIP-seq [21], Gro-seq [22], and RNA-seq [23], and key projects and consortia (e....
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...Insights are gained from studies of specific genes and gene networks [13-15], as well as from genome-wide studies [11, 16] utilizing methodologies such as PEAT [17], 5' RACE [18], CAGE [19], FAIRE-seq [20], ChIP-seq [21], Gro-seq [22], and RNA-seq [23], and key projects and consortia (e.g. modENCODE [24], ENCODE [25] and FANTOM5 [26]), which developed following the implementation of some of the above methods....
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4,673 citations
Additional excerpts
...Insights are gained from studies of specific genes and gene networks [13-15], as well as from genome-wide studies [11, 16] utilizing methodologies such as PEAT [17], 5' RACE [18], CAGE [19], FAIRE-seq [20], ChIP-seq [21], Gro-seq [22], and RNA-seq [23], and key projects and consortia (e....
[...]
...Insights are gained from studies of specific genes and gene networks [13-15], as well as from genome-wide studies [11, 16] utilizing methodologies such as PEAT [17], 5' RACE [18], CAGE [19], FAIRE-seq [20], ChIP-seq [21], Gro-seq [22], and RNA-seq [23], and key projects and consortia (e.g. modENCODE [24], ENCODE [25] and FANTOM5 [26]), which developed following the implementation of some of the above methods....
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3,424 citations
2,446 citations
"The core promoter: At the heart of ..." refers background in this paper
...subunit that in turn reaches the first codon, AUG, via a 5' UTR scanning mechanism (reviewed in [249])....
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2,312 citations