The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction.
Citations
1,332 citations
Cites background from "The coxsackievirus and adenovirus r..."
...It is noteworthy that overexpression of a recently identified TJassociated Rho GTPase-specific guanine nucleotide exchange factor (GEF/H1) increased the paracellular permeability to hydrophilic solutes without affecting TER (ion permeability) (20)....
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...Although its precise relationship to the TJ is somewhat controversial (31, 147), CAR coimmunoprecipitates with ZO-1....
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...Findings that the number of parallel strands and the complexity of the TJ network varies greatly among different pithelia led to the suggestion that there is a direct relationship between these and the measured transepithelial electrical resistance (TER) (30)....
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...By contrast, expression of claudin-4 chimeras, in which one or both extracellular domains of claudin-2 replaced those of claudin-4, increased the number of TJ strands, but alterations in TER and charge selectivity were only modest....
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...Cingulin JAM-1, ZO-1, ZO-2, ZO-3 Cross-linking TJ proteins to the actin cytoskeleton, bundling of F-actin filaments 18, 36 Symplekin Colocalizes with ZO-1 at TJ; also present in nucleus Processing of pre-mRNA and its polyadenylation 69, 83 ZONAB ZO-1, CDK4 Y-box transcription factor; by binding CDK4, ZONAB may regulate cell proliferation, may also regulate ErbB2 expression 11, 14 HuASH1 Transcription factor 108 GEF-H1 TJ-associated guanine nucleotide exchange factor; regulation of paracellular permeability but not TER 20 aPKC PAR-3, PAR-6 Establishment of cell polarity 40 PP2A TJ-associated protein phosphatase that regulates phosphorylation of aPKC, ZO-1, occludin, and claudin-1 110 Heterotrimeric G proteins ZO-1, ZO-2 Signaling molecules that participate in the regulation of TJ barrier function 100 Rab3b, Rab13 Recruited to junctional complexes following cell-cell contact, may be involved in vesicle targeting to cell-cell adhesion sites 94, 152, 166 Sec6/Sec8 Vesicle targeting to sites of cell-cell adhesion 58 PTEN MAGI-2, MAGI-3 Tumor suppressor; dephosphorylates phosphatidyl phosphates 160, 161 7H6 Not known Not known 167 TJ, tight junction....
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1,185 citations
Cites background from "The coxsackievirus and adenovirus r..."
...The latter molecule is CAR (Coxsackie- and adeno-virus receptor), which also participates in TJ assembly and in the regulation of paracellular permeability (65)....
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1,096 citations
920 citations
Cites background from "The coxsackievirus and adenovirus r..."
...and promote their localization at cell boundaries (32,33)....
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...JAM-A and coxsackie and adenovirus receptor, 2 examples of JAM proteins, have been shown to regulate epithelial barrier function, because expression of either protein leads to a reduction in paracellular permeability (31,32)....
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914 citations
Cites background from "The coxsackievirus and adenovirus r..."
...In CHO and MDCK cells, CAR overexpression decreases dextran permeability and increases TER [77]....
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...CAR is concentrated at cell-cell contacts and is co-localized with ZO-1 in intestinal T84 cells [77]....
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...The recombinant soluble CAR protein, which encodes the extracellular domain and inhibits the intercellular interaction of CAR, delays the recovery of TER after calcium repletion [77]....
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References
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