The crystal structure of copper glutamate dihydrate.
10 Oct 1966-Acta Crystallographica (International Union of Crystallography)-Vol. 21, Iss: 4, pp 594-600
About: This article is published in Acta Crystallographica.The article was published on 1966-10-10. It has received 65 citations till now. The article focuses on the topics: Copper.
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TL;DR: In this article, the synthesis and crystal structure of ammine ammine complex is described, where the copper atoms exhibit a square-pyramidal coordination with two N atoms and two O atoms in the base plane and one O atom at the apex of the pyramid.
Abstract: Synthesis and Crystal Structure of Ammine(μ3-L-glutamato)copper(II)
[Cu(L-Glu)H2O]·H2O reacts with aqueous ammonia to give the ammine complex [Cu(L-Glu)NH3] (1). 1 forms orthorhombic crystals, space group P 21212 with a = 1585,1(1) pm; b = 979,46(7) pm and c = 504,70(5) pm. In the crystal structure of 1 the copper atoms are linked by μ3-glutamate units to give a 2D layer structure. The copper atoms exhibit a square-pyramidal coordination with two N atoms and two O atoms in the base plane and one O atom at the apex of the pyramid. The crystal structure is stabilized by a 3D network of N–H···O hydrogen bridges.
DOI•
01 Jul 1986TL;DR: In this paper, the ambiguity in the assignment of stereochemistry and co-ordination to Cu(II) complexes can be resolved by using x-ray absorption spectroscopic technique.
Abstract: The ambiguity in the assignment of stereochemistry and co-ordination to Cu(II) complexes can be resolved by using x-ray absorption spectroscopic technique. The difficulty in the structural assignment of the Cu-glutamate complex is studied in detail. The Cu-acetylacetonate complex has also been studied as an example of square planar geometry. The Cu-glutamate complex is a distorted octahedral molecule.
01 Jan 2023
TL;DR: In this article , metal-organic framework (MOF) is defined as a class of well-ordered and crystalline porous coordination polymers which have a larger surface area, porous nature, tunable structure, and composition, they are intensely desirable in drug delivery.
Abstract: Metal–organic framework (MOF) is a class of well-ordered and crystalline porous coordination polymers. Research on advanced MOFs such as polymer-based MOFs and nanoparticle-based MOFs have been explored to a great extent in biomedical applications, especially in drug delivery systems. Nano-MOFs have been investigated and proved to be very effective for in vivo and in vitro drug delivery. Because nano-MOFs have a larger surface area, porous nature, tunable structure, and composition, they are intensely desirable in drug delivery. MOFs are classified according to their metals (Cu, Fe, Zr, Zn, and K) and organic frameworks. The functionalization of MOFs is accomplished through surface adsorption, covalent binding, and pore encapsulation. The efficiency of nano-MOFs in drug delivery is evaluated by their pharmacokinetic characteristics, including toxicity level, biosafety, ease of removal after drug delivery, and their bioavailability. The bioavailability of drug-loaded MOFs depends on mucosal penetration, gastric pH, metabolic enzymes, and physicochemical properties.
TL;DR: Coordination of oxyphosphorus ligands to pentaamminechromium(III) lowers the ligand field strength of the ammines to a much greater extent than trichloroacetate as mentioned in this paper.
Abstract: Coordination of oxyphosphorus ligands to pentaamminechromium(III) lowers the ligand field strength of the ammines to a much greater extent than trichloroacetate. This presumably signifies a weaker metal-nitrogen bond, and may contribute to the reluctance of the amines in aminophosphonate ligands to coordinate.
01 Jan 2014
TL;DR: In this paper, the formation of metal-amino acid complexes has been studied in several works, and the flexibility of amino acid molecules as ligands allows coordination of cations with different chemical properties (such as charge or ionic radius).
Abstract: This chapter deals with salts formed from metal cations and amino acid anions. All amino acids can act as monovalent anion; the acidic members glutamic acid and aspartic acid as well as cysteine and tyrosine can form both monovalent and divalent anions. Due to the large number of available cations, a multitude of combinations is possible and in fact found (for the standard twenty amino acids, over 150 crystal structures are published, and many more species have been characterized by other methods). Different hydration states (as reported for the pristine amino acid crystals) occur as well, and the existence of polymorphs is also documented for some cases. The formation of metal–amino acid complexes has been studied in several works (both for a given amino acid and a given cation), and the flexibility of amino acid molecules as ligands allows coordination of cations with different chemical properties (such as charge or ionic radius). Several coordination modes are found for amino acids – the molecules can act as monodentate, bidentate, tridentate, and bridging ligands. The connectivity of the coordination polyhedra of the metal cations is considered – isolated units are frequent, but chains and layers occur as well. Moreover, these units can connect via amino acid molecules to form higher-dimensional structures. Hydrogen bonds (also involving water molecules, both in coordination or in the interstices as crystal water) further stabilize the units, forming relatively stable phases. The frequency of salts varies among the different amino acids, and most examples are reported for glycinate salts, whereas crystals of cations and basic and weakly soluble amino acids are difficult to obtain (e.g., arginate and lysinate salts have not been reported in crystalline state). Finally, the aspect of symmetry is considered (the chirality of most amino acids playing a crucial role), and, consequently, the properties of these salts have impact on applications in the fields of physics, biology, and medicine.
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