Journal ArticleDOI
The cytokine networks of adaptive immunity in fish
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TLDR
The molecular, and increasing cellular, evidence for the existence of T-helper cells in fish is highlighted, and whether these cells will match exactly to the mammalian paradigm remains to be seen, but the early evidence suggests that there will be many similarities to known subsets.About:
This article is published in Fish & Shellfish Immunology.The article was published on 2013-12-01. It has received 260 citations till now. The article focuses on the topics: Acquired immune system & Antigen-presenting cell.read more
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Evolution of Innate Immunity: Clues from Invertebrates via Fish to Mammals
TL;DR: The high specificity, antibody maturation, immunological memory, and secondary responses of adaptive immunity were so successful that it allowed higher vertebrates to reduce the number of variants of the innate molecules originating from both invertebrates and lower vertebrates.
Journal ArticleDOI
The Function of Fish Cytokines
Jun Zou,Christopher J. Secombes +1 more
TL;DR: Such studies begin to tell us about the role of these molecules in the regulation of fish immune responses and whether they are similar or divergent to the well-characterised functions of mammalian cytokines, to improve fish health in aquaculture.
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Lactic Acid Bacteria in Finfish—An Update
TL;DR: Results indicate that LAB may vary in their immunological effects depending on the species and hosts, which includes their impacts on finfish aquaculture, possible routes for treatment and their interaction with fish immune responses.
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Virus genomes and virus-host interactions in aquaculture animals
Qi-Ya Zhang,Jian-Fang Gui +1 more
TL;DR: The wealth of genetic and genomic information from studies on a diverse range of aquatic viruses is reviewed, and some major advances in the understanding of virus-host interactions in animals used in aquaculture are outlined.
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Immunohistochemical characterization of Toll-like receptor 2 in gut epithelial cells and macrophages of goldfish Carassius auratus fed with a high-cholesterol diet
Eugenia Rita Lauriano,Simona Pergolizzi,Gioele Capillo,Michał Kuciel,Alessio Alesci,Caterina Faggio +5 more
TL;DR: Feeding goldfish, Carrassius auratus, a high-cholesterol diet (HCD) resulted macrophage foam cell formation in the intestinal tissues, and the expression of TLR2 has been found in foam cells and in the cytoplasm of enterocytes, however the staining was more intense at the apical surface of polarized intestinal epithelial cells and the lamina propria.
References
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Regulatory T Cells: Mechanisms of Differentiation and Function
TL;DR: Cellular and molecular mechanisms in the differentiation and function of regulatory T cells and their role in autoimmune and autoinflammatory disorders, allergy, acute and chronic infections, cancer, and metabolic inflammation are discussed.
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Regulation and Functions of the IL-10 Family of Cytokines in Inflammation and Disease
TL;DR: The IL-10 family of cytokines consists of nine members that can promote innate immune responses from tissue epithelia to limit the damage caused by viral and bacterial infections and facilitate the tissue-healing process in injuries caused by infection or inflammation.
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Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.
TL;DR: Lymphokine synthesis patterns of a panel of 19 T cell clones have been evaluated, using mRNA hybridization methods to examine 11 different mRNAs induced by Con A, and it is shown that secreted protein and mRNA levels correlated well for all cell lines.
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CD4⁺T cells: differentiation and functions
TL;DR: This paper will focus on the cytokine-signaling and the network of transcription factors responsible for the differentiation of naive CD4+T cells.
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IL-12 family cytokines: immunological playmakers
TL;DR: It is outlined how cells might interpret seemingly similar cytokine signals to give rise to the diverse functional outcomes that characterize this cytokine family, and the therapeutic implications of this complexity are discussed.