Open AccessDOI
The Cytotoxic and Antileishmanial Effects of Satureja khuzestanica Essential Oil
Farnaz Kheirandish,Rouzbeh Chegeni,Bahram Delfan,Mahboubeh Jabari,Farzad Ebrahimzadeh,Marzieh Rashidipour +5 more
- Vol. 1, Iss: 1, pp 11-17
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TLDR
The present research showed potent antileishmanial activity of S. khuzestanica essential oil; additionally this plant had no toxic effect on mammalian cells.Abstract:
Background and Aim: Leishmaniasis is endemic in 98 countries including Iran. Pentavalent antimony compounds resistance as first-line therapy is increasing in some local areas. Also side effects of these drugs are limited at the beginning of treatment, but the toxicity increases with time. The aim of this study was to assess the effect of Satureja khuzestanica essential oil (SKEO) on promastigote and amastigote Leishmania major forms. Materials and Methods: The components of S. khuzestanica oil were identified by gas chromatography/mass spectroscopy (GC/MS) analysis. To evaluate antipromastigote activity the different concentrations of extract and glucantime were added to the wells that contained L. major . The plates were incubated at 26±1°C for a week. On days 1, 3 and 5, the number of live promastigotes in each well was counted. For assessment of SKEO effect on intracellular amastigotes, mouse peritoneal macrophages were isolated and infected with promastigotes. Different concentrations of the extract and glucantime were added to the cultures. The cultures were incubated at 37°C and CO 2 5%. The number of infected macrophages and amastigotes within each macrophage were counted. Toxicity assessment of SKEO on macrophages was done by MTT method. Results and Conclusions: The mean number of promastigotes, infected macrophages and amastigotes in a macrophage in the control and treated groups had significantly difference. So that their number in the treated groups was less as a dose-dependent response. The present research showed potent antileishmanial activity of, SKEO; additionally this plant had no toxic effect on mammalian cells.read more
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Genes encoding members of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene family from Azadirachta indica and correlation with azadirachtin biosynthesis
Sweta Bhambhani,Sweta Bhambhani,Deepika Lakhwani,Deepika Lakhwani,Tapsi Shukla,Tapsi Shukla,Ashutosh Pandey,Yogeshwar Vikram Dhar,Yogeshwar Vikram Dhar,Mehar Hasan Asif,Mehar Hasan Asif,Prabodh Kumar Trivedi,Prabodh Kumar Trivedi +12 more
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Recent researches in effective antileishmanial herbal compounds: narrative review
TL;DR: This review of recent developments and reported studies concerning about herbal and naturally derived therapeutics in the treatment of leishmaniasis, conducted by several researchers worldwide, can serve as a quick reference database for researchers.
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Could Araucaria heterophylla resin extract be used as a new treatment for toxoplasmosis
Nora L El-Tantawy,Amal F. Soliman,Aida A. Abdel-Magied,Doaa Ghorab,Ashraf Taha Khalil,Zein M. Naeem,Kuniyoshi Shimizu,Saleh H. El-Sharkawy +7 more
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Isolation and antifungal activity evaluation of Satureja khuzestanica Jamzad extract against some clinically important dermatophytes.
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Anti-toxoplasmosis activity of herbal medicines: Narrative review
TL;DR: In this review, the information of those herbal medicines which are reported to have anti- Toxoplasma gondii activity is summarized and referred to the information databases of Medline, PubMed, Scopus and Google Scholar.
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