Journal ArticleDOI
The decline in skeletal muscle mass with aging is mainly attributed to a reduction in type II muscle fiber size.
Rachel Nilwik,Tim Snijders,Marika Leenders,Bart B. L. Groen,Janneau van Kranenburg,Lex B. Verdijk,Luc J. C. van Loon +6 more
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TLDR
Reduced muscle mass with aging is mainly attributed to smaller type II muscle fiber size and, as such, is unlikely accompanied by substantial muscle fiber loss.About:
This article is published in Experimental Gerontology.The article was published on 2013-05-01. It has received 522 citations till now. The article focuses on the topics: Muscle hypertrophy & Sarcopenia.read more
Citations
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Sarcopenic obesity in older adults: aetiology, epidemiology and treatment strategies.
TL;DR: The evolution, controversies and challenges in defining sarcopenic obesity are discussed, and current body composition modalities used to assess this condition are presented and current treatment strategies are outlined.
Journal ArticleDOI
Skeletal muscle performance and ageing
TL;DR: A broad overview on the underlying mechanisms associated with elderly skeletal muscle performance is provided and major implications for scientists, clinicians, and health professionals who are developing therapeutic interventions aiming to enhance muscle function and/or prevent mobility and physical limitations are developed.
Journal ArticleDOI
The age-related loss of skeletal muscle mass and function: Measurement and physiology of muscle fibre atrophy and muscle fibre loss in humans
TL;DR: Loss of muscle mass with age is due to atrophy and loss of individual muscle fibres, and anabolic resistance is fundamental in age-related fibre atrophy.
Journal ArticleDOI
Aging Is Accompanied by a Blunted Muscle Protein Synthetic Response to Protein Ingestion
Benjamin T. Wall,Stefan H. M. Gorissen,Bart Pennings,René Koopman,Bart B. L. Groen,Lex B. Verdijk,Luc J. C. van Loon +6 more
TL;DR: Ageing is associated with the development of muscle anabolic inflexibility which represents a key physiological mechanism underpinning sarcopenia and there was a strong negative correlation between post-absorptive muscleprotein synthesis rates and the increase in muscle protein synthesis rate following protein ingestion.
Journal ArticleDOI
Substantial skeletal muscle loss occurs during only 5 days of disuse.
Benjamin T. Wall,Marlou L. Dirks,Tim Snijders,Joan M. G. Senden,John Dolmans,L.J.C. van Loon +5 more
TL;DR: This work assessed the impact of 5 and 14 days of disuse on skeletal muscle mass, strength and associated intramuscular molecular signalling responses.
References
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Diagnosis and Classification of Diabetes Mellitus
TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.
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Skeletal muscle mass and distribution in 468 men and women aged 18–88 yr
TL;DR: It is indicated that men have more SM than women and that these gender differences are greater in the upper body.
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What is the cause of the ageing atrophy? Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15- to 83-year-old men
TL;DR: The results show that the ageing atrophy of this muscle begins around 25 years of age and thereafter accelerates, and suggest the occurrence of several other age-related adaptive mechanisms which could influence fiber sizes and fiber number, as well as enzyme histochemical fiber characteristics.
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Invited review: Aging and sarcopenia.
TL;DR: The link between sarc Openia and disability among elderly men and women highlights the need for continued research into the development of the most effective interventions to prevent or at least partially reverse sarcopenia, including the role of resistance exercise and other novel pharmacological and nutritional interventions.
Journal ArticleDOI
Strength conditioning in older men: skeletal muscle hypertrophy and improved function.
TL;DR: Strength gains in older men were associated with significant muscle hypertrophy and an increase in myofibrillar protein turnover and the torque-velocity relationship showed an upward displacement of the curve at the end of training, mainly in the slow-vel velocity high-torque region.
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Sarcopenia: Revised European consensus on definition and diagnosis
Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia.
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