The Detection of Androgen Receptor Splice Variant 7 in Plasma-derived Exosomal RNA Strongly Predicts Resistance to Hormonal Therapy in Metastatic Prostate Cancer Patients
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Cites background from "The Detection of Androgen Receptor ..."
...Similarly, exosomal AR-V7 mRNA has been used as a prognostic marker of resistance to hormonal therapy in metastatic prostate cancer patients [71]....
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371 citations
Cites background from "The Detection of Androgen Receptor ..."
...For instance, androgen receptor splice variant 7 (AR-V7) is detectable in plasma-derived exosomal RNA of patients with castration-resistant prostate cancer (CRPC) and may be a predictive biomarker of resistance to hormonal therapy in CRPC (4)....
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References
2,221 citations
"The Detection of Androgen Receptor ..." refers background or methods or result in this paper
...Antonarakis et al [1] found in circulating tumor cells (CTCs) that one splicing variant, androgen receptor splice variant 7 (AR-V7), is associated with resistance to enzalutamide and abiraterone....
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...Although in previous studies [1,18] AR-V7 levels increased over time, in our study only four of seven samples had increasing AR-V7 copies/ml....
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...In prostate cancer the only predictive biomarkers of resistance to therapy are the androgen receptor (AR) splice variants and DNA-repair deficiency, relative to hormonal therapy (HT) and poly(adenosine diphosphate-ribose) polymerase inhibitors, respectively [1,2]....
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...The comparison of CTCs [1] versus plasmaderived exosomes as a source of RNA (present study) demonstrates that CTC AR-V7 patients have a median OS of 8 mo versus not reached for AR-V7 patients [1], a result similar to the present study (8 mo vs not reached, respectively, AR-V7 vs AR-V7 patients)....
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...Several reports demonstrated and validated its role not only in vitro, but also in vivo [1,8,16,17]....
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1,694 citations
"The Detection of Androgen Receptor ..." refers background in this paper
...In prostate cancer the only predictive biomarkers of resistance to therapy are the androgen receptor (AR) splice variants and DNA-repair deficiency, relative to hormonal therapy (HT) and poly(adenosine diphosphate-ribose) polymerase inhibitors, respectively [1,2]....
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1,244 citations
1,028 citations
"The Detection of Androgen Receptor ..." refers background in this paper
...Therefore, LBD deletion results in loss of the antiandrogen binding site and constitutive activation of AR-V7 [6]....
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...The LBD is responsible for androgen-dependent receptor activity and the target of flutamide, bicalutamide, and enzalutamide [5,6]....
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531 citations
"The Detection of Androgen Receptor ..." refers background or result in this paper
...In a recent study on AR-V7 analysis on CTCs, it was shown that the incidence and amount of AR-V7 increase by line of therapy, reconfirming the role of AR-V7 as an acquired mechanism of resistance to systemic therapy [18]....
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...Although in previous studies [1,18] AR-V7 levels increased over time, in our study only four of seven samples had increasing AR-V7 copies/ml....
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