Journal ArticleDOI
The dual role of CD8+ T lymphocytes in the development of stress-induced herpes simplex encephalitis.
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TLDR
It is suggested that a delayed infiltration of CD8(+) T cells into the brain may promote HSE in naive mice, while the presence of HSV-specific T cells in the brain prior to HSV challenge is protective, possibly by limiting HSV replication and spread within the CNS.About:
This article is published in Journal of Neuroimmunology.The article was published on 2003-07-01. It has received 65 citations till now. The article focuses on the topics: Cytotoxic T cell & CD8.read more
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Journal ArticleDOI
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection.
TL;DR: This review concentrates on the other side of the bi-directional loop of neuroendocrine-immune interactions, namely, the characterization of HPA axis activity during viral infection and the mechanisms employed by cytokines to stimulate glucocorticoid release.
Journal ArticleDOI
Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation.
Aji Nair,Robert H. Bonneau +1 more
TL;DR: It is demonstrated that elevated levels of glucocorticoids are able to activate microglia in vivo and suggest that stress is able to induce a pro-inflammatory response within the central nervous system.
Journal ArticleDOI
Immune control of herpes simplex virus during latency
TL;DR: It is proposed that HSV-1-specific memory/effector CD8(+) T lymphocytes that are retained in the ganglion in close apposition to the neurons prevent full reactivation and virion formation through IFN-gamma production and an additional undefined mechanism(s).
Journal ArticleDOI
Herpes simplex type I (HSV-1) infection of the nervous system: is an immune response a good thing?
TL;DR: A greater understanding of the contribution of resident glial cells and infiltrating leukocytes within the CNS in response to HSV-1 invasion is necessary to identify candidate molecules as targets for therapeutic intervention to reduce unwarranted inflammation coinciding with the maintenance of the anti-viral state.
Journal ArticleDOI
Modulation of HLA-G Expression in Human Neural Cells after Neurotropic Viral Infections
Monique Lafon,Christophe Prehaud,Françoise Mégret,Mireille Lafage,Gaël Mouillot,Michèle Roa,Philippe Moreau,Nathalie Rouas-Freiss,Edgardo D. Carosella +8 more
TL;DR: It is shown here that two viruses—herpes simplex virus type 1 (HSV-1) and rabies virus (RABV), a neuronotropic virus triggering acute neuron infection—upregulate the neuronal expression of several HLA-G isoforms, including H LA-G1 and Hla-G5, the two main biologically active isoforms.
References
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Journal ArticleDOI
T-lymphocyte entry into the central nervous system
TL;DR: It is demonstrated that when T‐lymphoblasts are introduced into the circulation they rapidly appear in the CNS tissue, and lymphocytes which have entered, exit within 1 to 2 days.
Journal ArticleDOI
Restraint stress in biomedical research: A review
William P. Paré,Gary B. Glavin +1 more
TL;DR: The purpose of this review is to present a summary of the methods for, the parameters of, and known drug effects on, restraint-induced pathology.
Book ChapterDOI
Infection and spread of alphaherpesviruses in the nervous system.
Journal ArticleDOI
Herpes simplex encephalitis: An immunohistological study of the distribution of viral antigen within the brain
TL;DR: An immunoperoxidase technique was used to map the sites of herpes simplex virus antigen (VA) within the brain in 29 autopsied cases of herpessimplex encephalitis, and attention is drawn to focally extensive infection of the granule cell of the dentate fascia.
Journal ArticleDOI
Restraint stress differentially affects anti-viral cellular and humoral immune responses in mice
John F. Sheridan,Ningguo Feng,Robert H. Bonneau,Carl M. Allen,Brandon S. Huneycutt,Ronald Glaser +5 more
TL;DR: Physical restraint administered to C57BL/6 mice significantly altered the inflammatory response to influenza virus infection and depressed anti-viral cellular immunity, but the magnitude of the humoral immune response to flu virus was unaffected by restraint stress.