Journal ArticleDOI
The early history of antirheumatic drugs.
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This article is published in Arthritis & Rheumatism.The article was published on 1970-03-01. It has received 83 citations till now.read more
Citations
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Copper complexes of non-steroidal anti-inflammatory drugs: an opportunity yet to be realized
Jane E. Weder,Carolyn T. Dillon,Trevor W. Hambley,Brendan J. Kennedy,Peter A. Lay,J. Ray Biffin,Hubert Leonardus Regtop,Neal M. Davies +7 more
TL;DR: If the potential opportunities of the Cu-NSAIDs are to be completely realized, a mechanistic understanding and delineation of their in vivo and in vitro pharmacological activity is fundamental, along with further characterization of their pharmacokinetic/pharmacodynamic disposition.
Journal ArticleDOI
Treatment of rheumatoid arthritis
TL;DR: With an improved understanding of the pathophysiology of RA and the evidence from various clinical trials with the agents, early aggressive therapy with a combination of drugs or biological agents may be warranted for the effective treatment of RA.
Journal ArticleDOI
Rheumatoid Arthritis: An Overview of New and Emerging Therapies
Tanya Doan,Elena Massarotti +1 more
TL;DR: The pharmacological rationale underlying RA therapy is reviewed, with a focus on currently available biological therapies and new therapies in development.
Journal ArticleDOI
Treatment of early seropositive rheumatoid arthritis: A two-year, double-blind comparison of minocycline and hydroxychloroquine
James R. O'Dell,Kent Blakely,Jack A. Mallek,P. James Eckhoff,Robert D Leff,Steven Wees,Kelly M. Sems,Ana Fernández,William R Palmer,Lynell Warren Klassen,Gail A. Paulsen,Claire E. Haire,Gerald Francis Moore +12 more
TL;DR: Minocycline is an effective DMARD in patients with early seropositive rheumatoid arthritis and did so while receiving less prednisone, compared with a conventional disease-modifying antirheumatic drug, hydroxychloroquine.
References
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Book
The Greek Herbal of dioscorides
John Goodyer,R. T. Gunther +1 more
TL;DR: John Goodyer (1592–1664), described as “a forgotten botanist of the seventeenth century”, has survived among gardeners interested in the history of their craft.
Journal Article
The fate of acetophenetidin in man and methods for the estimation of acetophenetidin and its metabolites in biological material.
Bernard B. Brodie,Julius Axelrod +1 more
TL;DR: The analgesic and antipyretic action of acetophenetidin is exerted mainly through N-acetyl p-aminophenol which is an active analgesic but also has the potential to be a precursor of the substance which oxidizes hemoglobin to methemoglobin.
Journal ArticleDOI
Gold Therapy in Rheumatoid Arthritis.
Ellman P,Lawrence Js,Thorold Gp +2 more
TL;DR: Findlay, Mackenzie, and MacCallum (1940) have shown that infectious arthritis of rodents is due to a pleuropneumonia type of organism, and Swift and Brown (1939) claim to have isolated a Pleuropneuimonia-like organism from human cases of acute arthritis.
Journal ArticleDOI
The etiology of primary granulocytopenia (agranulocytic angina)
TL;DR: Dennis has attempted to incriminate focal infections by introducing various organisms in the experimental animal in a manner intended to simulate that type of infection in man and has found a tendency to occur constantly or even frequently in the clinical cases.