The effect of aqueous leaf extracts of Pterocarpus mildbraedii on crude oil-induced toxicity in Albino rats
14 Jun 2021-Journal of Herbs, Spices & Medicinal Plants (Informa UK Limited)-Vol. 27, Iss: 4, pp 365-376
TL;DR: Results showed that the administration of the P. mildbraedii leaf extract restored the levels of the plasma enzymes, blood proteins, urea, and creatinine close to normal control levels, which were altered by the crude oil-contaminated diet, and the number of chromosomal aberrations were fewer in treated rats than in the untreated intoxicated rats.
Abstract: This study evaluated the ameliorative potential of the aqueous leaf extracts of Pterocarpus mildbraedii against crude oil-induced toxicity in rats. The effects of co-administration of the P. mildbr...
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Journal Article•
TL;DR: BLCO exposure impaired fertility via increased oxidative stress and was not reversible upon withdrawal of treatment within the time course of investigation in male rats, which poses a risk for impaired fertility and its contribution to infertility in the Nigerian male population may not be excluded.
Abstract: BACKGROUND The reversibility of reproductive toxicity induced by the Nigerian Bonny light crude oil (BLCO) was investigated in rats. METHOD Adult male Wistar rats were orally treated with BLCO at 0, 50, 100 and 200mg kg(-1) for 21 days. One-half of the rats were sacrificed on day 22 while the remaining one-half stayed additional 21 days without treatment. RESULTS While sperm quality was compromised in dose-dependent manner, testis histopathology was only evident at 200 mg kg(-1) after 21 days. BLCO significantly decreased activities of superoxide dismutase, catalase and glucose-6-phosphate dehydrogenase but markedly elevated gamma glutamyltransferase and glutathione S-transferase activities as well as malondialdehyde, hydrogen peroxide and glutathione levels in both testes and sperm. Most of the above-mentioned parameters were consistent in animals from withdrawal experiment. CONCLUSION Taken together, BLCO exposure impaired fertility via increased oxidative stress and was not reversible upon withdrawal of treatment within the time course of investigation in male rats. BLCO exposure poses a risk for impaired fertility and its contribution to infertility in the Nigerian male population may not be excluded.
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TL;DR: In this review, a schematic approach is used that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, and abnormal enzymatic activity within the 2 subgroups are reviewed.
Abstract: ISOLATED ALTERATIONS OF BIOCHEMICAL MARKERS OF LIVER DAMAGE in a seemingly healthy patient can present a challenge for the clinician. In this review we provide a guide to interpreting alterations to liver enzyme levels. The functional anatomy of the liver and pathophysiology of liver enzyme alteration are briefly reviewed. Using a schematic approach that classifies enzyme alterations as predominantly hepatocellular or predominantly cholestatic, we review abnormal enzymatic activity within the 2 subgroups, the most common causes of enzyme alteration and suggested initial investigations.
1,488 citations
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01 Jul 1990TL;DR: Cardiovascular system pulmonary system neurological system autonomic nervous system gastrointestinal system skin and appendages eye ear nose, mouth and throat endocrine system haematopoietic system musculoskelatal system female genitalia general.
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