Journal ArticleDOI
The Effect of Fenugreek ( Trigonella foenum-graecum) Seed and 17-β Estradiol on Serum Apelin, Glucose, Lipids, and Insulin in Ovariectomized Rats
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TLDR
It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin.Abstract:
Background: Menopause, a natural phenomenon, is defined by the fall of ovarian hormones mainly estrogens causing major problems such as insulin resistance. Fenugreek (Trigonella foenum-graecum) is known to have some useful properties such as insulin sensitizing effect. Apelin is an adipokine, which has several roles such as regulation of insulin secretion.
Objectives: The objective of the present study was to evaluate the effect of fenugreek seed and 17-β estradiol on serum Apelin along with glucose, lipids and insulin in ovariectomized rats.
Materials and Methods: Forty-nine adult female Wistar rats were randomly divided to seven groups: normal control, ovariectomized control, ovariectomized treated with ethanolic and hexanic extract of fenugreek seed (50 and 150 mg/kg/daily for each), and ovariectomized treated with 17-β estradiol (10 μg/kg/daily) for 42 days. Serum Apelin, glucose, lipids and insulin were measured.
Results: Serum Apelin, glucose, lipids and insulin significantly increased in ovariectomized controls in comparison with normal controls (P < 0.05). Serum glucose, lipids and insulin in ovariectomized rats treated with fenugreek seed extract and 17-β estradiol were remarkably lower than ovariectomized controls (P < 0.05). Furthermore, 17-β estradiol caused a significant decrease (P < 0.05) in serum Apelin in ovariectomized rats.
Conclusions: It appears that fenugreek seed might be effective against hyperglycemia, hyperlipidemia and insulin resistance in ovariectomized rats without impact on serum Apelin. Furthermore, 17-β estradiol could have similar effects along with possible inhibitory effects on serum Apelin. The complicated role of Apelin in menopause needs to be further explored.
Keywords: Apelin-13; Trigonella Foenum-Graecum; 17 Beta-Estradiol; Ovariectomized; Insulin; Lipidsread more
Citations
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Journal ArticleDOI
Dose-dependent effects of fenugreek seed extract on the biochemical and haematological parameters in high-fat diet-fed rats.
Takkella Nagamma,Anjaneyulu Konuri,Chandrika D Nayak,Shobha U. Kamath,Padmanabha Udupa,Yogendra Nayak +5 more
TL;DR: It is suggested that fenugreek seed extract exhibits hypolipidaemic activity and significantly improves the activity of hepatic enzymes, and the blood counts and indices in rats with HFD-induced obesity.
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Therapeutic efficacy of fenugreek extract or/and Choline with docosahexaenoic acid in attenuating learning and memory deficits in ovariectomized rats
TL;DR: Therapeutic supplementation of FG with choline-DHA significantly attenuates ovariectomy-induced neurocognitive deficits in rats, causing significant improvement in learning and memory as well as decreased neural cell deficits compared to the same in OVX rats.
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Effect of phytoestrogens on lipid profile: mini review
TL;DR: The scope of use of phytoestrogen specifically pertaining to lipid profiling, their possible health benefits, and adverse effects if any are discussed, as well as the alternatives that mimic the beneficial effects of ERT.
Journal Article
Role of choline-docosahexaenoic acid and trigonella foenum graecum seed extract on ovariectomy induced dyslipidemia and oxidative stress in rat model
Nagamma Takkella,Anjaneyulu Konuri,Anoop Kishore,Kiranmai S. Rai,Kiranmai S. Rai,Kumar M.R. Bhat +5 more
TL;DR: Results showed that choline-DHA with TFG supplementation have a favorable effect on OVX induced hyperlipidemia and oxidative stress, therefore, these components may be a therapeutic agent for treating the menopause induced hyper Lipidemia or oxidative stress.
References
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TL;DR: Data suggest that, in contrast to a natural menopause, bilateral oophorectomy increases the risk of coronary heart disease, and this increase appears to be prevented by estrogen-replacement therapy.
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Apelin, a newly identified adipokine up-regulated by insulin and obesity
Jeremie Boucher,Bernard Masri,Danièle Daviaud,Stephane Gesta,Charlotte Guigné,Anne Mazzucotelli,Isabelle Castan-Laurell,Ivan Tack,Bernard Knibiehler,Christian Carpéné,Yves Audigier,Jean-Sébastien Saulnier-Blache,Philippe Valet +12 more
TL;DR: Apelin is identified as a novel adipocyte endocrine secretion and its potential link with obesity-associated variations of insulin sensitivity status is focused on and evidence that insulin exerts a direct control on apelin gene expression in adipocytes is provided.
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Executive summary of the Stages of Reproductive Aging Workshop +10: addressing the unfinished agenda of staging reproductive aging.
Siobán D. Harlow,Margery Gass,Janet E. Hall,Roger A. Lobo,Pauline M. Maki,Robert W. Rebar,Sherry Sherman,Patrick M. Sluss,Tobie J. de Villiers +8 more
TL;DR: STRAW +10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts and should improve comparability of studies of midlife women and facilitate clinical decision making.
Journal ArticleDOI
Executive summary of the Stages of Reproductive Aging Workshop + 10
Siobán D. Harlow,Margery Gass,Janet E. Hall,Roger A. Lobo,Pauline M. Maki,Robert W. Rebar,Sherry Sherman,Patrick M. Sluss,Tobie J. de Villiers +8 more
TL;DR: STRAW + 10 provides a more comprehensive basis for assessing reproductive aging in research and clinical contexts and should improve comparability of studies of midlife women and facilitate clinical decision making.