The effect of procaine on neuromuscular transmission.
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The mechanism of procaine action on post‐synaptic receptors for acetylcholine was studied by recording the end‐plate current at membrane potentials ranging from about +30 to about −140 mV.Abstract:
1. The mechanism of procaine action on post-synaptic receptors for acetylcholine was studied by recording the end-plate current at membrane potentials ranging from about +30 to about −140 mV.
2. It has been found that at resting membrane potential of about −60 to −80 mV the end-plate current has a fast initial and a slow late component. During hyperpolarization of the muscle fibre the amplitude of the slow component is depressed and its half-time lengthened. When the membrane potential is inverted the difference in the time course of both components is much less pronounced or absent.
3. It is suggested that procaine modifies the receptor response induced by acetylcholine, and that this modification is dependent on membrane potential.read more
Citations
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References
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On the permeability of end-plate membrane during the action of transmitter
A. Takeuchi,N. Takeuchi +1 more
TL;DR: In the present experiment, the e.p. c.c. equilibrium potential was measured in solutions of various ionic composition and the ions which contributed to the e-p.c., and the membrane potential at which it becomes zero may be called provisionally 'e.
Journal ArticleDOI
Active phase of frog's end-plate potential.
Akira Takeuchi,Noriko Takeuchi +1 more
TL;DR: The purpose of the present experiment was to determine directly the time course of the active phase of the e.
Journal ArticleDOI
Nature of the "endplate potential" in curarized muscle
Journal ArticleDOI
The Electrical Properties of the Muscle Fibre Membrane
TL;DR: The location of the membrane, or interface, at which electromotive changes occur is discussed, and a number of reasons are given which indicate that the site of the electrotonic potential changes must be at the surface of the muscle fibres.
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