Journal ArticleDOI
The effect of the shape of mesoporous silica nanoparticles on cellular uptake and cell function
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The results show that nanoparticles should no longer be viewed as simple carriers for biomedical applications, but can also play an active role in mediating biological effects, including cell proliferation, apoptosis, cytoskeleton formation, adhesion and migration.About:
This article is published in Biomaterials.The article was published on 2010-01-01. It has received 854 citations till now. The article focuses on the topics: Mesoporous silica & Nanoparticle.read more
Citations
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The physical impacts of microplastics on marine organisms: a review.
TL;DR: This review focuses on marine invertebrates and their susceptibility to the physical impacts of microplastic uptake and an assessment of the relative susceptibility of different feeding guilds.
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Mesoporous Silica Nanoparticles: Synthesis, Biocompatibility and Drug Delivery
TL;DR: The in vitro and in vivo biocompatibility and biotranslocation of MSNs are discussed in relation to their chemophysical properties including particle size, surface properties, shape, and structure.
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Endocytosis and intracellular transport of nanoparticles: Present knowledge and need for future studies
TL;DR: The use of pharmacological inhibitors, expression of mutated proteins, use of siRNAs and colocalization experiments in such studies are critically evaluated and aspects of intracellular transport, recycling of nanoparticle to the cell exterior, disturbance of cellular functions, and metabolism of nanoparticles are discussed.
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Smart micro/nanoparticles in stimulus-responsive drug/gene delivery systems
Mahdi Karimi,Amir Ghasemi,Parham Sahandi Zangabad,Reza Rahighi,S. Masoud Moosavi Basri,S. Masoud Moosavi Basri,Hamed Mirshekari,Mandana Amiri,Z. Shafaei Pishabad,A. Aslani,Mahnaz Bozorgomid,Deepanjan Ghosh,Ali Beyzavi,A. Vaseghi,Amir Reza Aref,L. Haghani,Sajad Bahrami,Michael R. Hamblin,Michael R. Hamblin +18 more
TL;DR: This review highlights the recent advances of smart MNPs categorized according to their activation stimulus (physical, chemical, or biological) and looks forward to future pharmaceutical applications.
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Challenges associated with Penetration of Nanoparticles across Cell and Tissue Barriers: A Review of Current Status and Future Prospects.
Sutapa Barua,Samir Mitragotri +1 more
TL;DR: This review focuses on the current understanding of penetration of NPs through biological barriers, andphasis is placed on transport barriers and not immunological barriers.
References
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A versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine
Otmane Boussif,Frank Lezoualc'h,Maria Antonietta Zanta,Mojgan Mergny,Daniel Scherman,Barbara A. Demeneix,Jean-Paul Behr +6 more
TL;DR: Together, these properties make PEI a promising vector for gene therapy and an outstanding core for the design of more sophisticated devices because its efficiency relies on extensive lysosome buffering that protects DNA from nuclease degradation, and consequent lysOSomal swelling and rupture that provide an escape mechanism for the PEI/DNA particles.
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Determining the size and shape dependence of gold nanoparticle uptake into mammalian cells.
TL;DR: The intracellular uptake of different sized and shaped colloidal gold nanoparticles is investigated and it is shown that kinetics and saturation concentrations are highly dependent upon the physical dimensions of the nanoparticles.
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Regulated portals of entry into the cell
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: ‘Endocytosis’ encompasses several diverse mechanisms by which cells internalize macromolecules and particles into transport vesicles derived from the plasma membrane and must be viewed in a broader context than simple vesicular trafficking.
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The effect of particle design on cellular internalization pathways
Stephanie E. A. Gratton,Patricia A. Ropp,Patrick D. Pohlhaus,J. Christopher Luft,Victoria J. Madden,Mary E. Napier,Joseph M. DeSimone +6 more
TL;DR: These findings suggest that HeLa cells readily internalize nonspherical particles with dimensions as large as 3 μm by using several different mechanisms of endocytosis, and it was found that rod-like particles enjoy an appreciable advantage when it comes to internalization rates.
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Role of target geometry in phagocytosis
TL;DR: It is reported that particle shape, not size, plays a dominant role in phagocytosis, and particle size primarily impacts the completion of phagocytes in cases where particle volume exceeds the cell volume.