Journal ArticleDOI
The effects of β-estradiol on SHSY5Y neuroblastoma cells during heavy metal induced oxidative stress, neurotoxicity and β-amyloid secretion
Gianfranco Olivieri,M Novakovic,Egemen Savaskan,Fides Meier,G. Baysang,M. Brockhaus,Franz Müller-Spahn +6 more
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TLDR
It is shown that β-estradiol exerts its neuroprotective action through mechanisms which reduce oxidative stress and reduce β-amyloid secretion, and contributes to a better understanding of the mode of action of estrogen with relevance to its use in the treatment of neurodegenerative disorders.About:
This article is published in Neuroscience.The article was published on 2002-09-10. It has received 103 citations till now. The article focuses on the topics: Neuroprotection & Neurotoxicity.read more
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Low dose mercury toxicity and human health.
TL;DR: Decreased performance in areas of motor function and memory has been reported among children exposed to presumably safe mercury levels and disruption of attention, fine motorfunction and verbal memory was also found in adults on exposure to low mercury levels.
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Gender differences in the disposition and toxicity of metals
TL;DR: Gender differences in susceptibility at lower exposure are uncertain, but recent data indicate that cadmium has estrogenic effects and affect female offspring, and experimental data suggest that females are more susceptible to immunotoxic effects of lead.
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Neurotrophic factors in Alzheimer's disease: role of axonal transport.
TL;DR: The interaction with neuropathological hallmarks Tau/neurofibrillary tangle and amyloid‐β (Abeta)/amyloid plaque pathology and their influence on axonal transport processes are focused on in order to unify AD‐specific cholinergic degeneration and Tau and Abeta misfolding through NTF pathophysiology.
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Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies.
TL;DR: The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.
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Mercury and autism: accelerating evidence?
TL;DR: It was hypothesized that children with autism have a decreased detoxification capacity due to genetic polymorphism, and promising treatments of autism involve detoxification of mercury, and supplementation of deficient metabolites.
References
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Journal ArticleDOI
The steroid and thyroid hormone receptor superfamily
TL;DR: A superfamily of regulatory proteins that include receptors for thyroid hormone and the vertebrate morphogen retinoic acid is identified, suggesting mechanisms underlying morphogenesis and homeostasis may be more ubiquitous than previously expected.
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Gene regulation by steroid hormones.
TL;DR: The location, orientation, and structure of the hormone regulatory elements (HRE) in nine hormonally modulated genes is described and a model for the interaction is proposed in which a dimer of the receptor in head-to-head orientation binds to the inverted symmetry element of the HRE.
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Effect of oestrogen during menopause on risk and age at onset of Alzheimer's disease
Ming-Xin Tang,Diane M. Jacobs,Yaakov Stern,Karen Marder,Peter W. Schofield,Barry J. Gurland,Howard Andrews,Richard Mayeux +7 more
TL;DR: Oestrogen use in postmenopausal women may delay the onset and decrease the risk of Alzheimer's disease and Prospective studies are needed to establish the dose and duration required to provide this benefit and to assess its safety in elderly post menopause women.
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A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
K. Hensley,John M. Carney,Mark P. Mattson,Marina V. Aksenova,Marni E. Harris,Ji Wu,R A Floyd,Butterfield Da +7 more
TL;DR: Evidence is presented that beta-amyloid fragments, at concentrations that previously have been shown to be neurotoxic to cultured neurons, can inactivate oxidation-sensitive glutamine synthetase and creatine kinase enzymes and generate free radical peptides.
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Estrogen Therapy in Postmenopausal Women: Effects on Cognitive Function and Dementia
TL;DR: There are plausible biological mechanisms by which estrogen might lead to improved cognition, reduced risk for dementia, or improvement in the severity of dementia, but large placebo-controlled trials are required to address estrogen's role in prevention and treatment of Alzheimer disease and other dementias.