The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers: a randomized trial in young overweight women
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Cites background from "The effects of intermittent or cont..."
...Several serum biomarkers of cancer risk also improved, but total and free IGF-1 did not change (Harvie et al., 2011)....
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...Several serum biomarkers of cancer risk also improve, but total and free IGF-1 do not change (Harvie et al., 2011)....
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926 citations
Cites background from "The effects of intermittent or cont..."
...Additional effects of fasting in human cells that can be considered as potentially ‘‘antiaging’’ are inhibition the mTOR pathway, stimulation of autophagy, and ketogenesis (Harvie et al., 2011; Sengupta et al., 2010)....
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...Results of initial trials of IF (fasting 2 days per week or every other day) in human subjects suggest that there is a critical transition period of 3–6 weeks during which time the brain and body adapt to the new eating pattern and mood is enhanced (Harvie et al., 2011; Johnson et al., 2007)....
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...Overweight subjects maintained for 6 months on a twice weekly IF diet in which they consumed only 500–600 calories on the fasting days, lost abdominal fat, displayed improved insulin sensitivity, and reduced blood pressure (Harvie et al., 2011)....
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...Examples include the ‘‘5:2’’ IF diet (Harvie et al., 2011), the alternate day modified fasting diet (Johnson et al....
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...Similarly, when on a 2 days/week fasting diet, overweight women at risk for breast cancer exhibited reduced oxidative stress and inflammation (Harvie et al., 2011), and elderly men exhibited reductions in body weight and body fat and improved mood (Teng et al....
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746 citations
730 citations
Cites background from "The effects of intermittent or cont..."
...Likewise, members of the Calorie Restriction Society, who follow the CRON (Calorie Restriction with Optimal Nutrition) diet,(43-45) have low rates of diabetes mellitus, with low levels of insulin-like growth factor 1, growth hormone, and markers of inflammation and oxidative stress.(4,20,33,43) A multicenter study showed that daily caloric restriction improves many cardiometabolic risk factors in nonobese humans....
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...However, these initial side effects usually disappear within 1 month, and patients should be advised of this fact.(17,20,27) Third, most physicians are not trained to prescribe specific intermittent-fasting interventions....
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...The women in the two groups lost the same amount of weight during the 6-month period, but those in the group assigned to 5:2 intermittent fasting had a greater increase in insulin sensitivity and a larger reduction in waist circumference.(20,27) Figure 3....
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655 citations
Cites background or methods or result from "The effects of intermittent or cont..."
...Thus on these days the energy restriction was similar to the planned 25% restriction in women taking CER (Harvie et al., 2011, 2013a)....
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...(Harvie et al., 2011, 2013a), and increased LDL particle size (Varady et al., 2011)....
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...Reductions of inflammatory markers with F are comparable to CER for a given weight loss (Harvie et al., 2011). hus, although limited, the available biomarker data suggest that IF eads to comparable changes in most cancer risk biomarkers to CER, ith the possible exceptions of insulin resistance and…...
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...Based on Harvie et al., 2011. ies have been relatively small and all reported equivalent weight loss between IF and CER....
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...We reported no change in total circulating IGF-1 alongside weight loss with IF or CER in either of our studies (Harvie et al., 2011, 2013a)....
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