The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.
L.M. Hallcher,W.R. Sherman +1 more
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TLDR
The effects of cholinergic agonists and antagonists on the enzyme were examined and found none and the possibility that the inhibition of this enzyme by lithium ion is related to the pharmacological actions of lithium is discussed.About:
This article is published in Journal of Biological Chemistry.The article was published on 1980-11-25 and is currently open access. It has received 1038 citations till now. The article focuses on the topics: Lithium chloride & Uncompetitive inhibitor.read more
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Inositol trisphosphate, a novel second messenger in cellular signal transduction.
TL;DR: Diacylglycerol operates within the plane of the membrane to activate protein kinase C, whereas inositol trisphosphate is released into the cytoplasm to function as a second messenger for mobilizing intracellular calcium.
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Inositol phosphates and cell signalling
TL;DR: The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
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Inositol trisphosphate and diacylglycerol as second messengers.
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Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
Christopher J. Phiel,Fang Zhang,Eric Y. Huang,Matthew G. Guenther,Mitchell A. Lazar,Peter S. Klein +5 more
TL;DR: It is proposed that inhibition of histone deacetylase provides a mechanism for valproic acid-induced birth defects and could also explain the efficacy of valproIC acid in the treatment of bipolar disorder.
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Regulation of Mammalian Autophagy in Physiology and Pathophysiology
Brinda Ravikumar,Sovan Sarkar,Janet E. Davies,Marie Futter,Moisés García-Arencibia,Zeyn W. Green-Thompson,Maria Jimenez-Sanchez,Viktor I. Korolchuk,Maike Lichtenberg,Shouqing Luo,Dunecan Massey,Fiona M. Menzies,Kevin Moreau,Usha Narayanan,Maurizio Renna,Farah H. Siddiqi,Benjamin R. Underwood,Ashley R. Winslow,David C. Rubinsztein +18 more
TL;DR: This review focuses on mammalian autophagy, and an overview of the understanding of its machinery and the signaling cascades that regulate it is given, and the possibility of autophagic upregulation as a therapeutic approach for various conditions is considered.
References
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The gel-filtration behaviour of proteins related to their molecular weights over a wide range
TL;DR: Correlation between elution volume, V(e), and molecular weight was investigated for gel filtration of proteins of molecular weights ranging from 3500 (glucagon) to 820000 (alpha-crystallin) on Sephadex G-200 columns at pH7.5.
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The direct linear plot. A new graphical procedure for estimating enzyme kinetic parameters
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A new micromethod for the colorimetric determination of inorganic phosphate.
Koichi Itaya,Michio Ui +1 more
TL;DR: A sensitive and simple technique was worked out for the colorimetric determination of inorganic phosphate, on the basis of the principle that Malachite Green at a lower pH forms a complex with phosphomolybdate with a marked shift of the absorption maximum.
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The enzymatic synthesis of inositol monophosphatide.
Henry Paulus,Eugene P. Kennedy +1 more
TL;DR: It is found that free inositol may be incorporated into lipid as a result of an enzymatic exchange reaction with inositl phosphatide present in the enzyme preparation.
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Reduced brain inositol in lithium-treated rats.
J. H. Allison,M. A. Stewart +1 more
TL;DR: The results of experiments that suggest an effect of lithium on the uptake or retention of myo-inositol by brain are reported.