The effects of variations in end-expiratory inflation pressure on cardiorespiratory function in normo-, hypo and hypervolaemic dogs
01 Aug 1970-BJA: British Journal of Anaesthesia (Oxford University Press)-Vol. 42, Iss: 8, pp 669-677
TL;DR: The effects of altering end-expiratory inflation pressure were studied in mechanically ventilated dogs in the normo, hypo- and hypervolaemic state, finding that the mean fall in cardiac output was smaller in the hyperVolaemic group than in the other two groups.
Abstract: SUMMARY The effects of altering end-expiratory inflation pressure were studied in mechanically ventilated dogs in the normo-, hypo- and hypervolaemic state. The mean fall in cardiac output resulting from an increase in end-expiratory pressure was smaller in the hypervolaemic group than in the other two groups. A positive end-expiratory pressure increased the mean deadspace/tidal volume ratio in all groups. A negative end-expiratory pressure increased venous admixture, particularly in the over-transfused animals, but the increase was not significant in the hypovolaemic group. A negative end-expiratory pressure did not affect deadspace/tidal volume ratio.
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