The EGFR family and its ligands in human cancer. signalling mechanisms and therapeutic opportunities.
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3,234 citations
Cites background from "The EGFR family and its ligands in ..."
...Upon ligand binding, these receptors form homo- or heterodimers (303)....
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...In addition, more distantly related proteins known as neuregulins (heregulins, neu differentiation factors, NDF 1–4) can also bind to some EGF receptor family members (303)....
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...The epidermal growth factor (EGF) family of mitogens comprises several members, including EGF, transforming growth factor- (TGF- ), heparin-binding EGF (HB-EGF), amphiregulin, epiregulin, betacellulin, neuregulins, the recently discovered epigen, as well as proteins encoded by Vaccinia virus and other poxviruses (263, 276, 303)....
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2,635 citations
Cites background from "The EGFR family and its ligands in ..."
...Ligand binding results in the formation of receptor homodomers and heterdimers leading to subsequent receptor activation and ultimately the activation of downstream signal transduction pathways (Yarden, 2001; Wiley, 2003)....
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References
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