The emergence of lncRNAs in cancer biology.
Citations
2,209 citations
Additional excerpts
...MiTranscriptome expression data Transcripts (381,821) Samples (6,475)...
[...]
1,593 citations
1,014 citations
Additional excerpts
...21 Functions as a transcriptional repressor [50,51]...
[...]
939 citations
797 citations
References
22,269 citations
15,665 citations
"The emergence of lncRNAs in cancer ..." refers background in this paper
...Moreover, whereas conventional cDNA microarrays detected only the transcripts represented by probes on the array, the introduction and popularization of RNA-Seq as a standard tool in transcriptome studies has removed many barriers to detecting all forms of RNA transcripts (9, 26)....
[...]
...These efforts will be facilitated by large-scale RNA-Seq studies followed by ab initio or de novo sequence data assembly to discover lncRNAs in an unbiased manner (9, 26)....
[...]
13,337 citations
5,091 citations
"The emergence of lncRNAs in cancer ..." refers background in this paper
...Still, their sheer abundance—some reports estimate that up to 70% of the human genome is transcribed into RNA (4)—has sparked debates as to whether ncRNA transcription reflects true biology or by-products of a leaky transcriptional system....
[...]
4,605 citations
"The emergence of lncRNAs in cancer ..." refers background in this paper
...By doing so, HOTAIR mediates the epigenetic repression of PRC2 target genes, and profiling of repressive (H3K27me3) and active (H3K4me3) chromatin marks shows widespread changes in chromatin structure following HOTAIR knockdown (28)....
[...]
...Supporting these findings, in benign immortalized breast cells overexpressing EZH2, a core component of PRC2, knockdown of HOTAIR mitigated EZH2induced invasion in vitro (28)....
[...]
...These observations raise the question, Are all Hox clusters regulated by lncRNAs, either by a cis-regulatory or by a trans-regulatory mechanism? In cancer, HOTAIR is upregulated in breast and hepatocellular carcinomas (10), and in breast cancer overexpression of HOTAIR is an independent predictor of overall survival and progression-free survival (28)....
[...]
...Dysregulated expression of lncRNAs in cancer marks the spectrum of disease progression (9) and may serve as an independent predictor for patient outcomes (28)....
[...]