The emerging mechanisms of isoform-specific PI3K signalling
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2,187 citations
Cites background from "The emerging mechanisms of isoform-..."
...effector of PI3K signaling and influences most phenotypes associated with PI3K pathway activation, it is worth noting that many other downstream effectors of PI3K exist that are activated in parallel to AKT and contribute to the subsequent cellular response (Vanhaesebroeck et al., 2010)....
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...Class I PI3Ks predominantly phosphorylate PI4,5P2, thereby producing PIP3 (Vanhaesebroeck et al., 2010), whereas the synthesis of PI3,4P2 typically follows, perhaps resulting from the action of the 50-phosphatase SH2-domain-containing inositol 50-phosphatase (SHIP) on PIP3 (Franke et al., 1997;…...
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...…studied effector of PI3K signaling and influences most phenotypes associated with PI3K pathway activation, it is worth noting that many other downstream effectors of PI3K exist that are activated in parallel to AKT and contribute to the subsequent cellular response (Vanhaesebroeck et al., 2010)....
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...Class I PI3Ks predominantly phosphorylate PI4,5P2, thereby producing PIP3 (Vanhaesebroeck et al., 2010), whereas the synthesis of PI3,4P2 typically follows, perhaps resulting from the action of the 50-phosphatase SH2-domain-containing inositol 50-phosphatase (SHIP) on PIP3 (Franke et al....
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1,593 citations
1,461 citations
Cites background from "The emerging mechanisms of isoform-..."
...Generation of mice with deletion or mutation of PI3K genes has been instrumental in delineating the unique and redundant functions of PI3K isoforms in mammalian cells and tissues (Okkenhaug, 2013; Vanhaesebroeck et al., 2010)....
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1,396 citations
1,239 citations
Cites background from "The emerging mechanisms of isoform-..."
...These enzymes also exist in three forms in mammalian cells: PI3KC2 , PI3KC2 , and PI3KC2 (1347, 1610)....
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...PI3KC3,(Vps34), PI3KC2A 4....
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References
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"The emerging mechanisms of isoform-..." refers background in this paper
..., as well as large-scale sequencing efforts of cancer genome...
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3,396 citations
"The emerging mechanisms of isoform-..." refers background in this paper
...sequenced the predicted kinase domains of the eight PI3K and eight PI3K-like genes in cancer and found tumour-specific (somatic) mutations only in PIK3CA , the gene encoding p110...
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2,742 citations