The endocannabinoid system as a target for novel anxiolytic drugs
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TLDR
Evidence that cannabidiol (CBD), while representing a less specific pharmacological approach, may be another way to modulate eCBs and interacting neurotransmitter systems to alleviate anxiety is reviewed.About:
This article is published in Neuroscience & Biobehavioral Reviews.The article was published on 2017-05-01 and is currently open access. It has received 164 citations till now. The article focuses on the topics: Anxiolytic & Endocannabinoid system.read more
Citations
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Natural Products from Cyanobacteria: Focus on Beneficial Activities.
TL;DR: The present review focuses on the beneficial activities of cyanobacterial molecules described so far and selected and specifically described 47 molecule families according to their respective bioactivities and their potential uses in pharmacology, cosmetology, agriculture, or other specific fields of interest.
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Integrating Endocannabinoid Signaling and Cannabinoids into the Biology and Treatment of Posttraumatic Stress Disorder.
TL;DR: It is proposed that a state of endocannabinoid deficiency could represent a stress susceptibility endophenotype predisposing to the development of trauma- related psychopathology and provide biologically plausible support for the self-medication hypotheses used to explain high rates of cannabis use in patients with trauma-related disorders.
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Medicinal Properties of Cannabinoids, Terpenes, and Flavonoids in Cannabis, and Benefits in Migraine, Headache, and Pain: An Update on Current Evidence and Cannabis Science
TL;DR: Knowledge of the individual medicinal properties of the cannabinoids, terpenes, and flavonoids is necessary to cross‐breed strains to obtain optimal standardized synergistic compositions, which will enable targeting individual symptoms and/or diseases.
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Animal models of PTSD: a challenge to be met
TL;DR: It is suggested that with an appropriate shift of practice, animal models are not only a valuable tool to enhance the authors' understanding of fear and memory processes, but could serve as effective platforms for understanding PTSD, for PTSD drug development and drug testing.
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Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders.
TL;DR: Compounds such as D-cycloserine, MDMA, L-DOPA and cannabinoids have shown efficacy in enhancing fear-extinction learning in humans, and are investigated in clinical trials as an augmentative strategy for speeding up and enhancing the long-term effectiveness of exposure-based psychotherapy.
References
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Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
Peter M. Zygmunt,Jesper Petersson,David Andersson,Huai-hu Chuang,Morten Sørgård,Vincenzo Di Marzo,David Julius,Edward D. Högestätt +7 more
TL;DR: It is shown that the vasodilator response to anandamide in isolated arteries is capsaicin-sensitive and accompanied by release of calcitonin-gene-related peptide (CGRP), which indicates that the vanilloid receptor may be another molecular target for endogenousAnandamide, besides cannabinoid receptors, in the nervous and cardiovascular systems.
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Molecular characterization of an enzyme that degrades neuromodulatory fatty-acid amides
Benjamin F. Cravatt,Dan K. Giang,Stephen P. Mayfield,Dale L. Boger,Richard A. Lerner,Norton B. Gilula +5 more
TL;DR: It is shown that oleamide hydrolase may serve as the general inactivating enzyme for a growing family of bioactive signalling molecules, the fatty-acid amides6–8, and the structure and sleep-inducing properties of cis-9-octadecenamide, a lipid isolated from the cerebrospinal fluid of sleep-deprived cats are reported.
PatentDOI
Modulation of anxiety through blockade of anandamide hydrolysis
TL;DR: In this paper, Fatty acid amide hydrolase inhibitors of the Formula (I) are provided, wherein X is NH, CH2, O, or S, Q is O or S; Z is O/N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unweighted biphenylyl, substituted or naphthyl, and substituted or unsaturated phenyl.