Journal ArticleDOI
The Endocannabinoidome in Neuropsychiatry: Opportunities and Potential Risks.
Gerwyn Morris,Ken Walder,Stefan Kloiber,Stefan Kloiber,Paul Amminger,Michael Berk,Michael Berk,Chiara C. Bortolasci,Michael Maes,Michael Maes,Michael Maes,Basant K. Puri,Andre F. Carvalho +12 more
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TLDR
The endocannabinoid system (ECS) comprises two cognate receptors referred to as CB1R and CB2R as discussed by the authors, which play an essential neuroprotective role by providing a defense against the development of glutamate-mediated excitotoxicity, which is achieved by impeding AMPA-mediated increase in intracellular calcium overload and oxidative stress.About:
This article is published in Pharmacological Research.The article was published on 2021-08-01. It has received 19 citations till now. The article focuses on the topics: Neuroprotection & Long-term depression.read more
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Assessing the role of ghrelin and the enzyme ghrelin O-acyltransferase (GOAT) system in food reward, food motivation, and binge eating behavior.
Emanuela Micioni Di Bonaventura,Luca Botticelli,Fabio Del Bello,Gianfabio Giorgioni,Alessandro Piergentili,Wilma Quaglia,Carlo Cifani,Maria Vittoria Micioni Di Bonaventura +7 more
TL;DR: In this article, the authors found that DAG and inhibition of GOAT may be targets for obesity and bingeing-related eating disorders and that AG/DAG ratio may be an important potential biomarker to assess the risk of developing maladaptive eating behaviors.
Journal ArticleDOI
Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract
TL;DR: A review of the endocannabinoidome, focusing on its modulatory role in the gastrointestinal tract and on the interest generated by the link between gut microbiota, the end-annabinoid system and metabolic diseases such as inflammatory bowel disease, type-2 diabetes and obesity, is presented in this paper .
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Biological hypotheses, risk factors, and biomarkers of schizophrenia
TL;DR: A summary of valid biological hypotheses of schizophrenia formulated based on risk factors and biomarkers, neurodevelopment, neuroplasticity, brain chemistry, and antipsychotic medication can be found in this article .
Journal ArticleDOI
Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders
TL;DR: In this article , the authors investigated the mechanisms underlying the ECS's regulation of redox signalling, as well as the mechanisms by which activated oxidative and nitrosative stress pathways may impair ECS-mediated signalling.
Journal ArticleDOI
Intertwined associations between oxidative and nitrosative stress and endocannabinoid system pathways: Relevance for neuropsychiatric disorders
Gerwyn Morris,Lukas Koch,Ken Walder,Michael Berk,Andre F. Carvalho,Wolf Marx,Chiara C. Bortolasci,Alison R. Yung,Basant K. Puri,Michael Maes +9 more
TL;DR: In this paper, the authors investigated the mechanisms underlying the ECS's regulation of redox signalling, as well as the mechanisms by which activated oxidative and nitrosative stress pathways may impair ECS-mediated signalling.
References
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Journal ArticleDOI
International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2
Roger G. Pertwee,Allyn C. Howlett,Mary E. Abood,Stephen P.H. Alexander,V. Di Marzo,Maurice R. Elphick,Peter J. Greasley,Harald S. Hansen,George Kunos,Ken Mackie,Raphael Mechoulam,Ruth Alexandra Ross +11 more
TL;DR: This review summarizes current data indicating the extent to which cannabinoid receptor ligands undergo orthosteric or allosteric interactions with non- CB1, non-CB2 established GPCRs, deorphanized receptors such as GPR55, ligand-gated ion channels, transient receptor potential (TRP) channels, and other ion channels or peroxisome proliferator-activated nuclear receptors.
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The orphan receptor GPR55 is a novel cannabinoid receptor
Erik Ryberg,Niklas Larsson,S. Sjögren,Stephan Hjorth,Nils-Olov Hermansson,J. Leonova,Thomas Elebring,Karolina Nilsson,Tomas Drmota,Peter J. Greasley +9 more
TL;DR: The endocannabinoid system functions through two well characterized receptor systems, the CB1 and CB2 receptors, and work by a number of groups in recent years has provided evidence that the system is more complicated and additional receptor types should exist to explain ligand activity in anumber of physiological processes.
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Endocannabinoid-Mediated Control of Synaptic Transmission
TL;DR: This review aims to integrate the current understanding of functions of the endocannabinoid system, especially focusing on the control of synaptic transmission in the brain, and summarizes recent electrophysiological studies carried out on synapses of various brain regions and discusses how synaptic transmission is regulated by endoc cannabinoidoid signaling.
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Mitogen-activated protein kinases in innate immunity
J. Simon C. Arthur,Steven C. Ley +1 more
TL;DR: This Review discusses the current knowledge about the regulation and the function of MAPKs in innate immunity, as well as the importance of negative feedback loops in limiting MAPK activity to prevent host tissue damage and how pathogens have evolved complex mechanisms to manipulate MAPK activation to increase their virulence.
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Neuroinflammation and M2 microglia: the good, the bad, and the inflamed.
TL;DR: The multiple possible activation states microglia can be polarized to are examined and particular attention is given to utilizing M2 microglial polarization as a potential therapeutic option in treating diseases.