Open AccessJournal Article
The enzymatic catabolism of hemoglobin: stimulation of microsomal heme oxygenase by hemin.
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This article is published in Journal of Laboratory and Clinical Medicine.The article was published on 1970-03-01 and is currently open access. It has received 390 citations till now. The article focuses on the topics: Heme oxygenase & Hemin.read more
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Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications.
TL;DR: The molecular and biochemical characterization of HOs is reviewed, with a discussion on the mechanisms of signal transduction and gene regulation that mediate the induction of HO-1 by environmental stress, to lay a foundation for potential future clinical applications of these systems.
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Heme oxygenase-1: unleashing the protective properties of heme
TL;DR: It is suggested that the products of HO-1 action could be valuable therapeutic agents and speculate thatHO-1 functions as a "therapeutic funnel", mediating the beneficial effects attributed to other molecules, such as interleukin-10 (IL-10), inducible nitric oxide synthase (NOS2; iNOS) and prostaglandins.
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Ferritin: a cytoprotective antioxidant strategem of endothelium.
György Balla,Harry S. Jacob,József Balla,Murray D. Rosenberg,Karl A. Nath,Fred S. Apple,John W. Eaton,Gregory M. Vercellotti +7 more
TL;DR: It is concluded that endothelium and perhaps other cell types may be protected from oxidant damage through the iron sequestrant, ferritin.
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Pharmacological and Clinical Aspects of Heme Oxygenase
Nader G. Abraham,Attallah Kappas +1 more
TL;DR: The use of pharmacological and genetic probes to manipulate HO, leading to new insights into the complex relationship of the HO system with biological and pathological phenomena under investigation, is reviewed.
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Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Lingyun Wu,Rui Wang +1 more
TL;DR: Understanding of the cellular and molecular mechanisms that regulate the production and mediate the physiological actions of CO has greatly advanced and many diseases, including neurodegenerations, hypertension, heart failure, and inflammation, have been linked to the abnormality in CO metabolism and function.