The epidermal growth factor receptor variant III (EGFRvIII): where wild things are altered
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TLDR
In this review, the evidence for the expression of EGFRvIII in a range of tumor types is critically analyzed and recent findings pertinent to its function and biology in GBM are discussed.Abstract:
The epidermal growth factor receptor (EGFR) is overexpressed in a variety of human epithelial tumors, often as a consequence of gene amplification. Tumors with EGFR gene amplification frequently contain EGFR gene rearrangements, with the most common extracellular domain mutation being EGFRvIII. This mutation leads to a deletion of exons 2-7 of the EGFR gene and renders the mutant receptor incapable of binding any known ligand. Despite this, EGFRvIII displays low-level constitutive signaling that is augmented by reduced internalization and downregulation. Aberrant EGFRvIII signaling has been shown to be important in driving tumor progression and often correlates with poor prognosis. It is clear that EGFRvIII is expressed in a considerable proportion of patients with glioblastoma multiforme (GBM). The presence of EGFRvIII in other tumor types, however, remains controversial. In this review, we critically analyze the evidence for the expression of EGFRvIII in a range of tumor types and discuss recent findings pertinent to its function and biology in GBM.read more
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Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Annette Becker,Basant Kumar Thakur,Joshua Mitchell Weiss,Han Sang Kim,Han Sang Kim,Héctor Peinado,David Lyden +6 more
TL;DR: Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
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TL;DR: The molecular mechanisms that regulate EGFR signal transduction are reviewed, including the EGFR structure and its mutations, ligand binding and EGFR dimerization, as well as the signaling pathways that lead to G1 cell cycle progression.
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Comprehensive Molecular Characterization of Papillary Renal-Cell Carcinoma.
W. Marston Linehan,Paul T. Spellman,Christopher J. Ricketts,Chad J. Creighton,Suzanne S. Fei,Caleb F. Davis,David A. Wheeler,Bradley A. Murray,Laura S. Schmidt,Cathy D. Vocke,Myron Peto,Abu Amar M. Al Mamun,Eve Shinbrot,Anurag Sethi,Samira A. Brooks,W. Kimryn Rathmell,Angela N. Brooks,Katherine A. Hoadley,A. Gordon Robertson,Denise Brooks,Reanne Bowlby,Sara Sadeghi,Hui Shen,Daniel J. Weisenberger,Moiz S. Bootwalla,Stephen B. Baylin,Peter W. Laird,Andrew D. Cherniack,Gordon Saksena,Scott M. Haake,Jun Li,Han Liang,Yiling Lu,Gordon B. Mills,Rehan Akbani,Mark D.M. Leiserson,Benjamin J. Raphael,Pavana Anur,Donald P. Bottaro,Laurence Albiges,Nandita Barnabas,Toni K. Choueiri,Bogdan Czerniak,Andrew K. Godwin,A. Ari Hakimi,Thai H. Ho,James J. Hsieh,Michael M. Ittmann,William Y. Kim,Bhavani Krishnan,Maria Merino,Kenna R. Mills Shaw,Victor E. Reuter,Ed Reznik,Carl Simon Shelley,Brian Shuch,Sabina Signoretti,Ramaprasad Srinivasan,Pheroze Tamboli,George Thomas,Satish K. Tickoo,Kenneth Burnett,Daniel Crain,Johanna Gardner,Kevin Lau,David Mallery,Scott Morris,Joseph Paulauskis,Robert Penny,Candace Shelton,W. Troy Shelton,Mark E. Sherman,Eric M. Thompson,Peggy Yena,Melissa T. Avedon,Jay Bowen,Julie M. Gastier-Foster,Mark Gerken,Kristen M. Leraas,Tara M. Lichtenberg,Nilsa C. Ramirez,Tracie Santos,Lisa Wise,Erik Zmuda,John A. Demchok,Ina Felau,Carolyn M. Hutter,Margi Sheth,Heidi J. Sofia,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jean C. Zenklusen,Jiashan Zhang,Brenda Ayala,Julien Baboud,Sudha Chudamani,Jia Liu,Laxmi Lolla,Rashi Naresh,Todd Pihl,Qiang Sun,Yunhu Wan,Ye Wu,Adrian Ally,Miruna Balasundaram,Saianand Balu,Rameen Beroukhim,Tom Bodenheimer,Christian J. Buhay,Yaron S.N. Butterfield,Rebecca Carlsen,Scott L. Carter,Hsu Chao,Eric Chuah,Amanda Clarke,Kyle R. Covington,Mahmoud Dahdouli,Ninad Dewal,Noreen Dhalla,Harsha Doddapaneni,Jennifer Drummond,Stacey Gabriel,Richard A. Gibbs,Ranabir Guin,Walker Hale,Alicia Hawes,D. Neil Hayes,Robert A. Holt,Alan P. Hoyle,Stuart R. Jefferys,Steven J.M. Jones,Corbin D. Jones,Divya Kalra,Christie Kovar,Lora Lewis,Jie Li,Yussanne Ma,Marco A. Marra,Michael Mayo,Shaowu Meng,Matthew Meyerson,Piotr A. Mieczkowski,Richard A. Moore,Donna Morton,Lisle E. Mose,Andrew J. Mungall,Donna M. Muzny,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Jacqueline E. Schein,Steven E. Schumacher,Yan Shi,Janae V. Simons,Payal Sipahimalani,Tara Skelly,Matthew G. Soloway,Carrie Sougnez,Angela Tam,Donghui Tan,Nina Thiessen,Umadevi Veluvolu,Min Wang,Matthew D. Wilkerson,Tina Wong,Junyuan Wu,Liu Xi,Jane Zhou,Jason Bedford,Fengju Chen,Yao Fu,Mark Gerstein,David Haussler,Katayoon Kasaian,Phillip H. Lai,Shiyun Ling,Amie Radenbaugh,David Van Den Berg,John N. Weinstein,Jingchun Zhu,Monique Albert,Iakovina Alexopoulou,Jeremiah J. Andersen,J. Todd Auman,John Bartlett,Sheldon I. Bastacky,Julie Bergsten,Michael L. Blute,Lori Boice,Roni J. Bollag,Jeff Boyd,Erik P. Castle,Ying-Bei Chen,John C. Cheville,Erin Curley,Benjamin Davies,April DeVolk,Rajiv Dhir,Laura Dike,John Eckman,Jay Engel,Jodi Harr,Ronald L. Hrebinko,Mei Huang,Lori Huelsenbeck-Dill,Mary Iacocca,Bruce L. Jacobs,Michael Lobis,Jodi K. Maranchie,Scott McMeekin,Jerome Myers,Joel Nelson,Jeremy Parfitt,Anil V. Parwani,Nicholas J. Petrelli,Brenda Rabeno,Somak Roy,Andrew Salner,Joel Slaton,Melissa L. Stanton,R. Houston Thompson,Leigh B. Thorne,Kelinda Tucker,Paul M. Weinberger,Cynthia Winemiller,Leigh Anne Zach,Rosemary E. Zuna +227 more
TL;DR: Type 1 and type 2 papillary renal-cell carcinomas were shown to be different types of renal cancer characterized by specific genetic alterations, with type 2 further classified into three individual subgroups on the basis of molecular differences associated with patient survival.
Journal ArticleDOI
Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge
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TL;DR: The hallmark genetic alterations that are associated with distinct epigenetic features and patient characteristics in both paediatric and adult disease are summarized, and the complex interplay between the glioblastoma genome and epigenome is examined.
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Focal adhesion signaling and therapy resistance in cancer
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TL;DR: Insight is given into the role of integrins in carcinogenesis, tumor progression and metastasis and literature and data about the function of focal adhesion molecules includingIntegrins, integrin-associated proteins and growth factor receptors in tumor cell resistance to radio- and chemotherapy will be elucidated and discussed.
References
More filters
Journal ArticleDOI
AMPK phosphorylation of raptor mediates a metabolic checkpoint.
Dana M. Gwinn,David B. Shackelford,Daniel F. Egan,Maria M. Mihaylova,Annabelle Mery,Debbie S. Vasquez,Benjamin E. Turk,Reuben J. Shaw +7 more
TL;DR: AMPK directly phosphorylates the mTOR binding partner raptor on two well-conserved serine residues, and this phosphorylation induces 14-3-3 binding to raptor, uncovering a conserved effector of AMPK that mediates its role as a metabolic checkpoint coordinating cell growth with energy status.
Journal ArticleDOI
Epidermal growth factor-related peptides and their receptors in human malignancies
Journal ArticleDOI
STATs in oncogenesis.
TL;DR: The evidence for critical roles of STATs in oncogenesis is presented and the potential for development of novel cancer therapies based on mechanistic understanding of STAT signaling is discussed.
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