The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
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Cites background from "The fat-derived hormone adiponectin..."
...Similarly, the acute administration of adiponectin to ob/ob mice improves fatty liver disease through suppression of TNF productio...
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3,045 citations
2,855 citations
Cites background from "The fat-derived hormone adiponectin..."
...Adiponectin also decreases hepatomegaly, steatosis and the levels of liver enzyme...
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2,525 citations
Cites background from "The fat-derived hormone adiponectin..."
...Adiponectin was reported to alleviate alcoholic and nonalcoholic fatty liver diseases (96, 97) and liver fibrosis (98) in mice....
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2,325 citations
References
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"The fat-derived hormone adiponectin..." refers background in this paper
...It can also improve dyslipidemia and decrease lipid accumulation in muscle, thus enhancing insulin sensitivity in this tissue (20)....
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...Adipose mRNA expression and plasma concentration of adiponectin are decreased dramatically in a variety of animal models as well as clinical patients with obesity, type 2 diabetes, and coronary heart disease (20, 46, 47)....
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...Administration of adiponectin into mice has been shown to produce beneficial effects on lipid metabolism, such as enhancing lipid clearance from plasma and increasing fatty acid β oxidation in muscle (20, 21)....
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...Recombinant adiponectin has been shown to be effective in increasing insulin sensitivity and in decreasing hyperlipidemia in several animal models (20, 41)....
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4,298 citations
"The fat-derived hormone adiponectin..." refers background in this paper
...Indeed, a more recent study has shown that full-length adiponectin can activate 5′-AMP–activated kinase in rat hepatocytes, which in turn will phosphorylate ACC and attenuate the activity of this enzyme (58)....
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3,172 citations
"The fat-derived hormone adiponectin..." refers background in this paper
...Adipose mRNA expression and plasma concentration of adiponectin are decreased dramatically in a variety of animal models as well as clinical patients with obesity, type 2 diabetes, and coronary heart disease (20, 46, 47)....
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