The Fibroblast Growth Factor signaling pathway
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...In chondrocytes, FGFR3 has been found to specifically activate STAT1 (Su et al. 1997; Sahni et al. 1999)....
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...In cultured chondrocytes, FGFR3 suppression of chondrocyte proliferation required MAPK signaling and was independent of STAT signaling (Raucci et al. 2004; Krejci et al. 2008a)....
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...Although the mechanism by which SNAIL1 regulates STAT1 and MAPK is not known, a recent report showed that SNAIL1 may regulate the nuclear localization of p-ERK (Smith et al. 2014)....
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...The function of the STAT1 and MAPK branches of the FGFR3 signal pathway may not be completely distinct....
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...Functionally, SNAIL1 appears to activate both the STAT1 and MAPK branches of the FGFR3 signaling pathway, as ectopic activation of SNAIL1 resulted in nuclear translocation of STAT1 and increased phosphorylation of ERK1/2 (de Frutos et al. 2007)....
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