The general transcription machinery and general cofactors.
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Cites background from "The general transcription machinery..."
...This event leads to the recruitment of the adaptor complexes such as SAGA (Green, 2005) or mediator, both of which in turn facilitate binding of general transcription factors (GTFs; Thomas and Chiang, 2006)....
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1,026 citations
Cites background from "The general transcription machinery..."
...In PIC assembly, general transcription factors , such as TATA-binding protein ( TBP ) or TFIID, bind to core promoter elements and position other initiation factors, such as TFIIB and TFIIF, which then direct Pol II to initiate transcription at the initiator element (INR element) (the consensus sequence is TCAKTY in flies and YYANWYY in humans...
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References
7,841 citations
"The general transcription machinery..." refers background in this paper
..., 2001), similar to H3-H4 tetramers and H2A-H2B dimers found in a nucleosome (Luger et al., 1997)....
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...This motif present in histone-like TAFs suggests that a TAF9TAF6 heterotetramer and two of the TAF4b-TAF12 heterodimer may form a histone octamer-like structure (Selleck et al., 2001), similar to H3-H4 tetramers and H2A-H2B dimers found in a nucleosome (Luger et al., 1997)....
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5,186 citations
"The general transcription machinery..." refers background in this paper
...Indeed, some transcription factors, such as hypoxia-inducible factor 1α (HIF-1α), are able to inhibit transcription by inducing NC2 activity that, in turn, blocks PIC assembly (Denko et al., 2003)....
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...…normaxia), in which recognition of the hydroxylated proline (mediated by prolyl-4-hydroxylase) by the hydrophobic pocket located at the β-domain of pVHL (Hon et al., 2002; Min et al., 2002) eventually leads to the ubiquitination and degradation of HIF-1α (Jaakkola et al., 2001; Ivan et al., 2001)....
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...For examples, Rsp5 shows preference for assembling K48-linked polyubiquitin chains on WW domain-binding protein 2 (WBP2; Kee et al., 2005) and K63-linked polyubiquitin chains on the yeast plasma membrane protein uracil permease (Galan and Haguenauer-Tsapis, 1997); the pVHL complex promotes K48-linked polyubiquitination leading to HIF-1α degradation (Ohh et al., 2000); BRCA1/BARD1 enhances K6-linked polyubiquitination on nucleophosmin (Sato et al., 2004) as well as autoubiquitination on BRCA1 through K6, K29, K48, or K63 linkage (Chen et al., 2002; Wu-Baer et al., 2003; Xia et al., 2003; Nishikawa et al., 2004)....
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...The requirement of an oxidized P1465 for pVHL binding is reminiscent of that seen with P564 of HIF-1α in oxygenated cells (during normaxia), in which recognition of the hydroxylated proline (mediated by prolyl-4-hydroxylase) by the hydrophobic pocket located at the β-domain of pVHL (Hon et al., 2002; Min et al., 2002) eventually leads to the ubiquitination and degradation of HIF-1α (Jaakkola et al., 2001; Ivan et al., 2001)....
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4,753 citations
4,480 citations
"The general transcription machinery..." refers background in this paper
...…normaxia), in which recognition of the hydroxylated proline (mediated by prolyl-4-hydroxylase) by the hydrophobic pocket located at the β-domain of pVHL (Hon et al., 2002; Min et al., 2002) eventually leads to the ubiquitination and degradation of HIF-1α (Jaakkola et al., 2001; Ivan et al., 2001)....
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3,565 citations
"The general transcription machinery..." refers background in this paper
..., 2001) and human PRC2 (Cao et al., 2002; Kuzmichev et al., 2002), PRC3 (Kuzmichev et al....
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...Given that the identified human PRC1 complex containing only homologs of the Drosophila core complex (PC, PH, PSC, and RING1) is able to inhibit SWI/SNF-mediated chromatin remodeling (Levine et al., 2002) and that the other characterized Drosophila PRC2 (Ng et al., 2000a; Tie et al., 2001) and human PRC2 (Cao et al., 2002; Kuzmichev et al., 2002), PRC3 (Kuzmichev et al., 2004), and PRC4 (Kuzmichev et al., 2005) complexes do not seem to contain TAFs, the functional roles of TAFs and the other subunits constituting PRC1 await further investigation....
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...…chromatin remodeling (Levine et al., 2002) and that the other characterized Drosophila PRC2 (Ng et al., 2000a; Tie et al., 2001) and human PRC2 (Cao et al., 2002; Kuzmichev et al., 2002), PRC3 (Kuzmichev et al., 2004), and PRC4 (Kuzmichev et al., 2005) complexes do not seem to contain TAFs,…...
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