The genetic architecture of type 2 diabetes
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...For others, such as RREB1 (MIM: 602209), identification of T2D-associated coding variants, statistically independent of the original GWAS signal, flags the likely effector transcripts.(74) All in all, it is possible to point to a compelling effector transcript at around one-third of the 100 T2D loci identified by GWASs....
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...Recent efforts to extend GWASs beyond arraybased genotyping and to access a broader range of variants through sequencing (particularly those of lower frequency) have revealed that most genetic variation influencing T2D appears to reside at common variant sites.(74,77) This chimes with the viewof T2D as a largely post-reproductive trait and is consistent with a failure to detect compelling empirical evidence that T2D risk alleles have been subject to marked purifying selection....
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