The Genetics of Autism Spectrum Disorders
Citations
1,760 citations
1,115 citations
Cites background from "The Genetics of Autism Spectrum Dis..."
...…in CNTNAP2 (which encodes Caspr2) are associated with epilepsy and cognitive decline as well as peripheral nerve involvement (Strauss et al., 2006), and have also been identified in various forms of schizophrenia, epilepsy and autism spectrum disorders (reviewed in Kumar and Christian, 2009)....
[...]
...It is interesting that mutations in genes encoding both these proteins are found in hereditary epilepsy and other disorders (reviewed by Morante-Redolat et al., 2002; Kumar and Christian, 2009), reflecting the fact that genetic and autoimmune conditions often target the same proteins....
[...]
1,023 citations
650 citations
542 citations
Cites background from "The Genetics of Autism Spectrum Dis..."
...Although ASD has a strong polygenetic component with heritability around 70% (Geschwind, 2011), no biological marker is available yet and thus, diagnosis mainly relies on behavioral assessment....
[...]
...This imbalance in the brain’s handling of prediction errors could result from different genetic and neurophysiological pathways, thus highlighting that different pathogenetic factors could in fact contribute to a common information processing imbalance (Geschwind, 2011)....
[...]
References
5,143 citations
2,770 citations
2,378 citations
2,033 citations
1,919 citations