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The Global Impact of Dementia 2013-2050

About: The article was published on 2013-12-01 and is currently open access. It has received 245 citations till now. The article focuses on the topics: Dementia.

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Journal ArticleDOI
TL;DR: The authors in this article found that 30.23% of the total global burden of disease is attributable to disorders in people aged 60 years and older, and the leading contributors to disease burden in older people are cardiovascular diseases, malignant neoplasms (15·1%), chronic respiratory diseases (9·5%), musculoskeletal diseases (7·5), and neurological and mental disorders (6·6%).

1,377 citations

Journal ArticleDOI
TL;DR: There is sufficiently strong evidence, from a population‐based perspective, to conclude that regular physical activity and management of cardiovascular risk factors reduce the risk of cognitive decline and may reduce therisk of dementia.
Abstract: An estimated 47 million people worldwide are living with dementia in 2015, and this number is projected to triple by 2050. In the absence of a disease-modifying treatment or cure, reducing the risk of developing dementia takes on added importance. In 2014, the World Dementia Council (WDC) requested the Alzheimer's Association evaluate and report on the state of the evidence on modifiable risk factors for cognitive decline and dementia. This report is a summary of the Association's evaluation, which was presented at the October 2014 WDC meeting. The Association believes there is sufficient evidence to support the link between several modifiable risk factors and a reduced risk for cognitive decline, and sufficient evidence to suggest that some modifiable risk factors may be associated with reduced risk of dementia. Specifically, the Association believes there is sufficiently strong evidence, from a population-based perspective, to conclude that regular physical activity and management of cardiovascular risk factors (diabetes, obesity, smoking, and hypertension) reduce the risk of cognitive decline and may reduce the risk of dementia. The Association also believes there is sufficiently strong evidence to conclude that a healthy diet and lifelong learning/cognitive training may also reduce the risk of cognitive decline.

1,146 citations


Cites background from "The Global Impact of Dementia 2013-..."

  • ...An estimated 47million peopleworldwide are living with dementia in 2015 [1], and this number is projected to triple by 2050 [2]....

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Journal ArticleDOI
02 Mar 2015-BMJ
TL;DR: The paradigm shift needed to fully institute tailored treatments for people and families dealing with these symptoms in the community is discussed and non-pharmacologic approaches with the strongest evidence base involve family care giver interventions are discussed.
Abstract: Behavioral and psychological symptoms of dementia include agitation, depression, apathy, repetitive questioning, psychosis, aggression, sleep problems, wandering, and a variety of inappropriate behaviors. One or more of these symptoms will affect nearly all people with dementia over the course of their illness. These symptoms are among the most complex, stressful, and costly aspects of care, and they lead to a myriad of poor patient health outcomes, healthcare problems, and income loss for family care givers. The causes include neurobiologically related disease factors; unmet needs; care giver factors; environmental triggers; and interactions of individual, care giver, and environmental factors. The complexity of these symptoms means that there is no “one size fits all solution,” and approaches tailored to the patient and the care giver are needed. Non-pharmacologic approaches should be used first line, although several exceptions are discussed. Non-pharmacologic approaches with the strongest evidence base involve family care giver interventions. Regarding pharmacologic treatments, antipsychotics have the strongest evidence base, although the risk to benefit ratio is a concern. An approach to integrating non-pharmacologic and pharmacologic treatments is described. Finally, the paradigm shift needed to fully institute tailored treatments for people and families dealing with these symptoms in the community is discussed.

801 citations

Journal ArticleDOI
TL;DR: Overall, hippocampal subfield analysis has proven to be a promising technique in the study of AD, however, harmonization of segmentation protocols and studies on larger samples are needed to enable accurate comparisons between studies and to confirm the clinical utility of these techniques.

257 citations

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